ǂa ǂtheoretical study
Beate Knoke (Author), Marko Marhl (Author), Stefan Schuster (Author)

Abstract

Calcium oscillations play an important role in intracellular signal transduction. As a second messenger, ▫$Ca^{2+}$▫ represents a link between several input signals and several target processes in the cell. Whereas the frequency of simple ▫$Ca^{2+}$▫ oscillations enables a selective activation of a specific protein and herewith a particular process, the question arises of how at the same time two or more classes of proteins can be specifically regulated. The question is general and concerns the problem of how one second messenger can transmit more than one signal simultaneously (bow-tie structure of signalling). To investigate whether a complex ▫$Ca^{2+}$▫ signal like bursting, a succession of low-peak and high-peak oscillatory phases, could selectively activate different proteins, several bursting patterns with simplified square pulses were applied in a theoretical model. The results indicate that bursting ▫$Ca^{2+}$▫ oscillations allow a differential regulation of two different calcium-binding proteins, and hence, perform the desired function.

Keywords

biofizika;kalcijeve oscilacije;celična dinamika;matematični modeli;ne zaključna dela;biophysics;calcium oscillations;cellular dynamics;mathematical models;signalling;bow-tie structures;bursting;decoding;

Data

Language: English
Year of publishing:
Typology: 1.16 - Independent Scientific Component Part or a Chapter in a Monograph
Organization: UM PEF - Faculty of Education
UDC: 539.19:577
COBISS: 15940360 Link will open in a new window
Views: 1977
Downloads: 37
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Other data

Secondary language: Slovenian
Secondary keywords: Biofizika;Matematični modeli;
URN: URN:SI:UM:
Type (COBISS): Article
Pages: Str. 11-22
DOI: 10.1007/978-0-8176-4558-8_2
ID: 8724147