Diagnostic and prognostic markers in canine inflammatory and neoplastic head and neck conditions

dissertation

Ana Rejec (Author), Janoš Butinar (Mentor)

Abstract

Several different types of conditions with inflammatory and neoplastic background affect the anatomical localities of the head and neck in a dog. It is a well-recognized fact that these conditions affect the quality of life, as they are associated with various degree of regional dysfunction, have systemic effects and can be direct or indirect cause of death. Unfortunately, many dogs with both inflammatory and neoplastic head and neck conditions are presented at an advanced stage of the disease which can have significant impact on treatment strategies. The identification of biomarkers is advisable to enhance effective staging, grading and prognostication, which will in turn more accurately direct recommendations for therapy. These biomarkers can theoretically help to distinguish between inflammatory and neoplastic conditions, justify the management of patients more accurately and potentially predict the prognosis and the survival of patients. It was our interest to investigate the diagnostic and prognostic value of complete blood count parameters and indices in dogs with head and neck conditions of inflammatory and neoplastic origin, regulatory T cells in dogs with periodontal disease, immunohistochemical (Ki-67 and VEGFR-2) and histopathological biomarkers in dogs with inflammatory and neoplastic head and neck conditions and to evaluate the effectiveness of an accelerated radiotherapy protocol for the treatment of advanced canine HNSCC. We have proved that the parameters investigated might serve as important supportive diagnostic and/or prognostic biomarkers which might help to improve the treatment strategies of both inflammatory and neoplastic head and neck conditions in dogs and that the accelerated chemoradiotherapy protocol represents an effective alternative treatment option for dogs with advanced HNSCC.

Keywords

biomarkers;dogs;periodontal disease;regulatory T cells;head and neck tumours;complete blood count;radiotherapy;vascular endothelial growth factor receptor 2;

Data

Language:	English
Year of publishing:	2015
Typology:	2.08 - Doctoral Dissertation
Organization:	UNG FPŠ - Graduate School
Publisher:	[A. Rejec]
UDC:	577
COBISS:	4077307
Views:	5238
Downloads:	108
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	biomarkerji;psi;parodontalna bolezen;regulatorne T celice;tumorji;radioterapija;disertacije;
URN:	URN:SI:UNG
Type (COBISS):	Doctoral dissertation
Thesis comment:	Univ. v Novi Gorici, Fak. za podiplomski študij
Pages:	210 str.
ID:	9077409