Maja Leitgeb (Author), Katja Heržič (Author), Gordana Hojnik Podrepšek (Author), Aljaž Hojski (Author), Anton Crnjac (Author), Željko Knez (Author)

Abstract

Nanoparticles of inorganic magnetic core surrounded by layers of functional coatings are potential representatives of nanostructures for immobilization of bio-substances. Magnetic nanoparticles (MNPs) are often bound in aggregates due to a strong magnetic dipole, which has a lot of advantages, such as large surface area for binding biologically active substances. Chitosan is a polysaccharide polymer that is non-toxic, hydrophilic, biocompatible and has hydroxy and amino groups in its structure. Because of these chemical and biological properties it is a desirable bio-product for immobilization of enzymes and for binding of other biologically active substances. Magnetic micro and nanoparticles were synthesized with chitosan by three different methods; microemulsion process, suspension cross-linking technique and covalent binding of chitosan. Toxic effect of the prepared magnetic particles was determined as well and was examined on five different bacterial cultures; Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis and Klebsiella pneumoniae. At concentrations of 10-30 mg of magnetic particles per 0.5 McFarland Standard solution of E. coli and per 400 CFU of S. aureus, P. aeruginosa, E. faecalis in K. pneumonia, no inhibition on the chosen bacterial cultures was detected.

Keywords

hitozan;biosubstance;magnetni nanodelci;magnetni mikrodelci;biološko aktivne snovi;toksikološki testi;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: Slovensko kemijsko društvo
UDC: 577.114.4
COBISS: 4955199 Link will open in a new window
ISSN: 1318-0207
Views: 1179
Downloads: 58
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Other data

Secondary language: Slovenian
Secondary abstract: Nanodelci iz magnetnega anorganskega jedra, oblečeni z večslojno funkcionalno prevleko, predstavljajo pomemben razred nanostrukturiranih delcev za vezavo biosubstanc. Zaradi možnega magnetnega dipola se magnetni nanodelci pogosto združujejo v skupke, kar pa ima številne prednosti, kot na primer velika površina, na katero lahko pritrdimo različne biološke komponente. Hitozan je polisaharidni polimer, ki je nestrupen, hidrofilen, biokompatibilen in vključuje prisotnost hidroksilne in amino skupine v svoji strukturi. Zaradi naštetih kemijskih in bioloških lastnosti spada hitozan med zaželjene biomateriale za imobilizacijo encimov in vezavo drugih biološko aktivnih substanc. Magnetne nanodelce, prevlečene s hitozanom, smo pripravili po treh različnih postopkih; s postopkom mikroemulzije, s postopkom suspenzijske zamreževalne tehnike ter s postopkom kovalentne vezaven hitozana. Toksikološke vplive pripravljenih magnetnih delcev smo preverili na petih različnih bakterijskih kulturah; Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis in Klebsiella pneumoniae. Pri koncentracijah 10-30 mg magnetnih delcev na 0.5 McFarland standardne raztopine bakterijske kulture E.coli in na 400 CFU bakterijskih kultur S. aureus, P. aeruginosa, E. faecalis in K. pneumonia do inhibicije rasti mikroorganizmov ni prišlo.
Secondary keywords: hitozan;biosubstance;magnetni nanodelci;magnetni mikrodelci;biološko aktivne snovi;toksikološki testi;
URN: URN:NBN:SI
Type (COBISS): Scientific work
Pages: str. 145-152
Volume: ǂVol. ǂ61
Issue: ǂno. ǂ1
Chronology: 2014
ID: 9108880