MicroRNA polymorphisms in cancer

ǂa ǂliterature analysis

Veronika Pipan (Author), Minja Zorc (Author), Tanja Kunej (Author)

Abstract

Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes (miR-SNPs) have attracted increasing attention in recent years due to their involvement in the development of various types of cancer. Therefore, a systematic review on this topic was needed. From 55 scientific publications we collected 20 SNPs, which are located within 18 miRNA encoding genes and have been associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are located within the premature miRNA region, five within mature, and two within mature seed miRNA region. We graphically visualized a network of miRNA-cancer associations which revealed miRNA genes and cancer types with the highest number of connections. Our study showed that, despite a large number of variations currently known to be located within miRNA genes in humans, most of them have not yet been tested for association with cancer. MicroRNA SNPs collected in this study represent only 0.43% of known miRNA gene variations (20/4687). Results of the present study will be useful to researchers investigating the clinical use of miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic targets.

Keywords

molekularna genetika;mikro RNK;polimorfizem;medicina;rak;

Data

Language:	English
Year of publishing:	2015
Typology:	1.01 - Original Scientific Article
Organization:	UL BF - Biotechnical Faculty
UDC:	575:616
COBISS:	3609992
ISSN:	2072-6694
Views:	1057
Downloads:	265
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	molekularna genetika;mikro RNK;polimorfizem;medicina;rak;
Type (COBISS):	Article
System comment:	Sistemske zahteve: spletni brskalnik, Adobe Acrobat Reader
Pages:	str. 1806-1814
Volume:	ǂVol. ǂ7
Issue:	ǂIss. ǂ3
Chronology:	2015
DOI:	10.3390/cancers7030863
ID:	9142304