magistrsko delo
Mojca Brglez (Author), Norbert Jaušovec (Mentor), Estera Žalik (Co-mentor)

Abstract

Parkinsonova bolezen je napredujoča nevrodegenerativna bolezen, katere vzrok ni povsem poznan. Znano je, da se lahko pred tipično motorično simptomatiko pojavijo nemotorični simptomi. Eden izmed njih je tudi upad vohalne sposobnosti. Namen naše raziskave je bil raziskati vohalno sposobnost in kognitivni status pri bolnikih s Parkinsonovo boleznijo. Želeli smo ugotoviti, kateri faktorji najbolje ločujejo testno skupino od kontrolne. Uporabili smo nov vohalni test, zato smo karakteristike testa preverili tudi pri mladih odraslih. V raziskavo smo vključili 30 bolnikov s Parkinsonovo boleznijo (povprečne starosti 68,8 let) in 30 starostnikov (povprečne starosti 71,2 let), ki so sestavljali kontrolno skupino. Vohalno sposobnost smo merili z vohalnim testom, ki smo ga napravili za potrebe te raziskave. Naloga udeležencev na tem testu je bila, da med desetimi pari različnih dišavnic najdejo ustrezne pare vonjev. Kognitivno učinkovitost smo ocenili z Montrealsko lestvico spoznavnih sposobnosti (MoCA). V drugo raziskavo smo vključili 100 mladih odraslih (povprečne starosti 23,3 let). Pri njih smo preverjali vohalno sposobnost z razširjenim vohalnim testom, ki je obsegal trinajst parov dišavnic. Rezultati so pokazali na statistično pomembno razliko v vohalni sposobnosti in kognitivnem upadu med bolniki s Parkinsonovo boleznijo in kontrolno skupino. Povezava med kognitivno učinkovitostjo in sposobnostjo voha je pri bolnikih šibka. Ugotovili smo tudi, da se s trajanjem bolezni vohalni deficit ne poslabšuje. Vonji, ki najbolje diskriminirajo testno skupino od kontrolne, so: kava, klinčki, majaron in cimet. Rezultati analize vohalnega testa pri mladih kažejo, da mladi na vohalnem testu dosegajo statistično pomembno boljše rezultate. Ugotovili smo tudi, da se pri origanu, majaronu, baziliki, rožmarinu, janežu in kumini pojavlja največ napak. Z vohalnim testom smo potrdili, da je pri bolnikih s Parkinsonovo boleznijo vohalna sposobnost slabša. To nam daje priložnost, da z izboljšanjem vohalnega testa in dodatnimi analizami na večjem vzorcu bolnikov uporabimo test kot presejalni in kot pomoč pri prepoznavi Parkinsonove bolezni že v predklinični fazi.

Keywords

magistrska dela;Parkinsonova bolezen;vohalna sposobnost;kognitivni upad;vohalni testi;Montrealska lestvica sposobnosti;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UM FF - Faculty of Arts
Publisher: [M. Brglez]
UDC: 159.953.2:616.858(043.2)
COBISS: 22602248 Link will open in a new window
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Other data

Secondary language: English
Secondary title: Correlation between olfactory dysfunction (hyposmia) and cognitive impairment in Parkinson's disease
Secondary abstract: Parkinson's disease is a progressive neurodegenerative disease with not fully known cause. It is known that the non-motor symptoms can appear before motor symptoms, which are typical. One of them is a decline in olfactory function. The aim of our study was to investigate the olfactory function and cognitive status of patients with Parkinson's disease. We wanted to determine which factors are best to differ the test group and a control group. We used new type of olfactory test, so we also checked the characteristics of the test with young adults. The study included 30 patients with Parkinson's disease (average age 68.8 years) and 30 elderly people (average age 71.2 years) who made up the control group. Olfactory function was measured by olfactory test, which we used for the purposes of this research. The task of the participants in this test was finding 10 pairs of different smelling spices. Cognitive efficiency was assessed by Montreal Cognitive Assessment (MoCA). The second study included 100 young adults (average age 23.3 years). We assessed olfactory function with extended olfactory test, which included 13 pairs of spices. The results showed a statistically significant difference between patients with Parkinson's disease and a control group in olfactory function and cognitive decline. Relationship between cognitive performance and the ability to smell is weak with patients. We also found that the olfactory deficit does not deteriorate with the duration of the disease. Scents that discriminate best between the test and the control group are: coffee, cloves, marjoram and cinnamon. Results of the analysis of the olfactory test in young adults show that they achieve statistically significantly better results. We also found that most errors occur with oregano, marjoram, basil, rosemary, anise, and caraway. With our olfactory test we confirmed the deterioration in olfactory function of Parkinson's disease patients. By improving the olfactory test and making additional analyses with the use of a larger sample of patients, we have the opportunity to use it as a screening test and as an aid in diagnosing Parkinson's disease in the pre-clinical phase.
Secondary keywords: master theses;Parkinson's disease;olfactory function;cognitive impairment;olfactory tests;Montreal cognitive assessment;
URN: URN:SI:UM:
Type (COBISS): Master's thesis/paper
Thesis comment: Univ. v Mariboru, Filozofska fak., Oddelek za psihologijo
Pages: III, 67 f.
ID: 9166023