Bioinformatska analiza molekularno bioloških poti raka materničnega vratu

diplomsko delo univerzitetnega študijskega programa

Maja Ferlež (Author), Uroš Potočnik (Mentor), Katja Repnik (Co-mentor)

Abstract

Rak je kompleksna genetska bolezen. Na nastanek in razvoj raka vplivajo tako okoljski dejavniki kot tudi sama genetika. Med vrste raka spada tudi rak materničnega vratu. V diplomski nalogi smo se opredelili na RMV in njegove podoblike ( SCC, AC, ASC, MM). RMV je eden od najpogostejših vzrokov smrti zaradi raka pri ženskah. Pojavlja se v različnih oblikah in je zelo heterogena bolezen. Glavni namen diplomske naloge je bil s podatkovnimi zbirkami genske ontologije in ustreznimi bioinformatskimi orodji ( DAVID 6.7, BioMart) identificirati oziroma raziskati genetiko posamezne podoblike RMV in na podlagi dobljenih zadetkov predpostaviti molekularno biološko pot nastanka različnih oblik RMV. Nadaljnji namen naloge je bil z bioinformatskimi orodji poiskati skupne gene in biološke mehanizme, ki vodijo do nastanka različnih oblik RMV. S pomočjo GWA študij smo dobili 6 skupnih genov in 4 biološke poti. Zaradi pomanjkanj raziskav RMV pa smo se opredelili tudi na gene, ki sodelujejo pri somatskih mutacijah. S pomočjo podatkovnih zbirk in orodij genske ontologije smo dobili 6 skupnih genov in 16 bioloških poti. Ti rezultati naj bi nam dali boljši vpogled v sam nastanek in razvoj te bolezni ter napredek pri iskanju novih možnosti za zdravljenje te bolezni.

Keywords

rak materničnega vratu;ploščatocelični karcinom;adenokarcinom;maligni melanom;genska otologija;genetika;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2016
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[M. Ferlež]
UDC:	618.14-006(043.2)
COBISS:	20097302
Views:	1287
Downloads:	104
Average score:	0 (0 votes)
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Other data

Secondary language:	English
Secondary title:	BIOINFORMATIC ANALYSIS OF MOLECULAR BIOLOGICAL PATHWAYS OF CERVICAL CANCER
Secondary abstract:	Cancer is a complex genetic disease. On the formation and development of cancer affecting both environmental factors as well as genetics itself. Among the types of cancer includes cancer of the cervix. In this thesis we have identified in cervical cancer and its subspecies (SCC, AC, ASC, MM). RMV is one of the most common causes of cancer deaths in women. It appears in various forms and is a very heterogeneous disease. The main purpose of this study was to gene ontology databases and corresponding bioinformatics tools (DAVID 6.7, Biomart) to identify and investigate the genetics of a particular subspecies of cervical cancer and on the basis of the results received to assume a molecular biological route of various forms of cervical cancer. A further aim of the study was to bioinformatics tools to find common genes and biological mechanisms that lead to the formation of various forms of cervical cancer. Through GWA studies give 6 shared genes and 4 of a biological pathway. Due to the lack of research RMV, we are also determined to genes involved in somatic mutations. With the help of databases and tools of gene ontology we got 6 common genes and 16 biological way. These results should give us a better insight into the origins and development of this disease and the progress made in the search for new treatment options for this disease.
Secondary keywords:	cancer of the cervix;cervial cancer;squamous cell carcinoma;SCC;adenocarcinoma;AC;malignant melanoma;MM;gene ontology;GO;genetic;
URN:	URN:SI:UM:
Type (COBISS):	Undergraduate thesis
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	VIII, 36 f.
ID:	9168071