magistrsko delo
Petra Sever (Author), Saška Lipovšek Delakorda (Mentor), Andraž Stožer (Co-mentor)

Abstract

Diabetes, pankreatitis, rak na trebušni slinavki so samo nekatere od številnih bolezni, ki so vzrok za raziskovanje trebušne slinavke. Modelni organizem teh raziskav je miš (Mus musculus), ki veliko prispeva k znanju v humani medicini. Trebušna slinavka je druga največja prebavna žleza v trebušni votlini. Je eksokrina žleza, ki izloča prebavne sokove in endokrina žleza, ki regulira glukozno homeostazo. Zanimali sta nas struktura in ultrastruktura treh različnih delov trebušne slinavke miši; duodenalnega, spleničnega in gastričnega režnja. Trebušno slinavko miši smo odstranili iz trebušne votline in analizirali prej omenjene dele s pomočjo svetlobne in transmisijske elektronske mikroskopije. Ugotovili smo, da so velikosti Langerhansovih otočkov med različnimi strukturnimi deli trebušne slinavke miši med seboj primerljivi. Do statistično pomembnih razlik pa je prišlo med velikostmi glukagonskih veziklov in granul, inzulinskih veziklov in granul, velikosti somatostatinskih granul ter velikosti zimogenih granul acinusa. Le med najdaljšim premerom somatostatinskih granul v duodenalnem in spleničnem delu trebušne slinavke nismo zaznali statističnih razlik. Deleži endokrinih in eksokrinih granul v različnih strukturnih delih trebušne slinavke so med seboj primerljivi. Med samimi deli trebušne slinavke miši ni strukturnih razlik, so pa zaznavne razlike v ultrastrukturi. Dobljene rezultate smo primerjali z že objavljenimi rezultati in ugotovili, da so med seboj skladni.

Keywords

magistrska dela;Langerhansovi otočki;endokrine celice;eksokrine celice;mišja trebušna slinavka;struktura;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UM FNM - Faculty of Natural Sciences and Mathematics
Publisher: [P. Sever]
UDC: 591.437:599.323.451(043.2)
COBISS: 22976264 Link will open in a new window
Views: 1726
Downloads: 238
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Other data

Secondary language: English
Secondary title: Microscopic and ultrastructural features of the cells from the duodenal, splenic, and gastric lobe of the mouse pancreas
Secondary abstract: Diabetes, pancreatitis and pancreatic cancer are only some of the many diseases which provide us with a reason to perform studies of the pancreas. The mouse (Mus musculus), as a model organism for pancreas research, can be considered one of the more important sources of knowledge for the field of Human Medicine. The pancreas is the second largest digestive gland inside the abdomen. It functions both as an exocrine gland, excreting gastric juices, and as an endocrine gland, regulating the homeostasis of glucose. This work focused on the study of the structure and ultrastructure of the duodenal, splenic, and gastric lobes of the mouse pancreas. After removing the pancreas from the abdomen of the mouse, we analyzed its structural parts using light microscopy and transmission electron microscopy. The results of this work indicate that the sizes of islets of Langerhans of different structural parts of the mouse pancreas do not differ. Additionally, it was determined that statistically significant differences between the sizes of glucagon vesicles and granules, insulin granules and vesicles, somatostatin granules and acinar zymogen granules exist. No statistical differences in the longest diameters of somatostatin granules between the duodenal and the splenic lobes were observed. Additional analysis showed that the ratios of endocrine and exocrine granules between different structural parts of the mouse pancreas do not differ. Structural differences of the lobes of the mouse pancreas were not observed, though differences in the ultrastructure were seen. No large differences were found when comparing the results of this work with other results obtained from other published literature.
Secondary keywords: master theses;islets of Langerhans;endocrine cells;exocrine cells;mouse pancreas;structure;
URN: URN:SI:UM:
Type (COBISS): Master's thesis/paper
Thesis comment: Univ. v Mariboru, Fak. za naravoslovje in matematiko, Oddelek za biologijo
Pages: X, 50 f.
ID: 9578109