Nove metode za ocenjevanje tveganja za razvoj metaboličnega sindroma pri otrocih

doktorska disertacija

Bernarda Vogrin (Author), Marjan Rupnik (Mentor), Jurij Dolenšek (Thesis defence commission member), Pavel Skok (Thesis defence commission member), Ivan Krajnc (Thesis defence commission member), Dušanka Mičetić-Turk (Co-mentor)

Abstract

Uvod. Zaradi epidemije otroške debelosti in metaboličnega sindroma lahko v prihodnosti pri otrocih pričakujemo še večje obremenitve srca in žil, čemur smo priča danes. Zgodnje odkrivanje oseb, ki so nagnjene k metaboličnim motnjam in boleznim srca in žil, lahko bistveno pripomore k načrtovanju preventive in zdravljenju bolezni. Hipoteza. Z merjenjem žilne funkcije, telesne sestave in natančno analizo serumskih lipidov lahko odkrijemo nagnjenost k metaboličnemu sindromu in boleznim srca in žil že v otroštvu, še pred pojavom kliničnih znakov. Metode. V študiji je sodelovalo 81 šolarjev starih 11–16 let. Z anketnim vprašalnikom smo pridobili podatke o njihovem socialnem okolju, prehranskih navadah in učnem uspehu. Z analizo športno vzgojnih kartonov smo ocenili njihovo telesno zmogljivost. Opravili smo meritve telesne konstitucije: telesno višino (TV), telesno težo (TT), obseg pasu (OP) in bokov (OB), kožno gubo na nadlahti (KGN) ter izračunali indeks telesne mase (BMI) in standardni odklon glede na spol in starost (SDS BMI). Telesno sestavo (odstotek maščobe (FAT %)) smo ocenjevali z bioimpedanco. Lastnosti arterijskega sistema smo merili z Arteriografom, z določanjem augmentacijskega indeksa (AIx), hitrosti pulznih valov (PWV) in centralnega sistoličnega arterijskega tlaka (SBPao). V vzorcu venozne krvi smo analizirali glukozo (GLU) in serumske lipide vključno s prostimi maščobnimi kislinami (PMK). Rezultati. AIx je značilno koreliral s TV, učnim uspehom, nekaterimi motoričnimi testi in serumskimi lipidi. PWV je značilno koreliral s TT, TV, BMI, SDS BMI, OP, OB, nekaterimi motoričnimi testi in PMK. SBPao je negativno koreliral z učnim uspehom. FAT % je kazal značilne povezave z GLU, PMK in drugimi lipidi. Pri 5 % oziroma 6 % učencev smo ugotovili zelo visoke vrednosti AIx, SBPao in PWV. Zaključki. AIx, PWV, PMK in FAT % so dobri pokazatelji začetnih žilnih in metaboličnih nepravilnosti pri otrocih in mladostnikih. Zvečana AIx in SBPao sta povezana s slabšimi učnimi in motoričnimi sposobnostmi. PWV je pri otrocih in mladostnikih zelo odvisen od telesne konstitucije.

Keywords

otroška debelost;metabolični sindrom;tveganje;srčno-žilne nepravilnosti;ugotavljanje;motorični testi;Bolezni metabolizma;Disertacije;Pediatrija;Metabolni sindrom;Debelost;Otroci;Sladkorna bolezen;

Data

Language:	Slovenian
Year of publishing:	2017
Typology:	2.08 - Doctoral Dissertation
Organization:	UM MF - Faculty of Medicine
Publisher:	[B. Vogrin]
UDC:	616-008.9-053.2(043.3)
COBISS:	6168127
Views:	840
Downloads:	102
Average score:	0 (0 votes)
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Other data

Secondary language:	English
Secondary title:	New mathods for metabolic syndrome risk evaluation in children
Secondary abstract:	Introduction: In the wake of epedemics of obesity and metabolic syndrome, we can expect the human heart and vessels to be exposed to even more pressures than we are witnessing at present. Early detection of persons who are prone to metabolic dysfunction and heart or vessel related diseases can offer an important contribution to preventive measures and the healing of diseases. Hypothesis: By measuring vessel function, body constitution and an accurate analysis of serum lipids we can discover the propensity to metabolic syndrome and heart diseases early in childhood, even before the appearance of clinical symptoms. Methods: The study featured 81 pupils aged 11-16. They completed a survey which gave us information about their social enviroment, eating habits and school success. Though analysis of the results of the Slofit programme we evaluated the body fitness of subjects. We measured body constitution, height, weight, waist circumference and hip circumference and upper arm skinfold and calculated the body mass index (BMI) and standard deviation according to the sex and age of the subjects (SDS BMI). Body compositon, the body fat percentage (FAT% ) was evaluated by bioimpedance. Charasteristics of the arterial system ware measured with an Arteriograph by determining the augmentation index (AIx), pulse wave velocity (PWV) and central systolic arterial pressure (SBPao). We analysed glucose (GLU) serum lipids along with free fatty acids (FFA) in samples of venous blood. Results: The augmentation index correlated as typically, with height, school success, some motoric tests and serum lipids. PWV showed significant correlation with body weight, height, BMI, SDS BMI, waist circumference, hip circumference, some motor tests and FFA. SBPao showed a negative correlation with school success. FAT% showed a significant correlation with GLU, FFA and other lipids. We detected very high values of AIx, SPBao and PWV in 5 pupils (6%). Conclusion: AIx, PWV, FFA and FAT% are good indicators of early vascular and metabolic disorders in children and adolescents. Increased AIx and SBPao are related to decreased school learning and motor abilities. PWV in children highly depends on body constitution.
Secondary keywords:	Metabolic syndrome;augmentation index;pulse vawe velocity;children;bioimpedance;
URN:	URN:SI:UM:
Type (COBISS):	Dissertation
Thesis comment:	Univ. v Mariboru, Medicinska fak.
Pages:	59 f.
ID:	9592652