diplomska naloga
Barbara Pogorelčnik (Author), Darinka Brodnjak-Vončina (Mentor), Mitja Kolar (Co-mentor)

Abstract

Namen diplomskega dela je izdelava NIR (angl. Near Infrared) modela za potrjevanje identitete vstopnih sušenih pomožnih spojin. Analizirane so bile naslednje spojine: natrijev saharinat, natrijev saharinat dihidrat, mikrokristalna celuloza, silificirana mikrokristalna celuloza, mešanica mikrokristalne celuloze in Na karboksimetilceluloze, polivinilpirolidon in Na karboksimetilceluloza. Izdelava NIR metode je sestavljena iz treh glavnih delov: načrtovanje metode, razvoj statističnega modela in validacija izdelane metode. Vsem vzorcem smo z refleksijsko sondo, povezano z NIR instrumentom, posneli NIR spektre. Za izdelavo modela smo uporabili matematični postopek metode glavnih osi (angl. Principal Component Analysis). Izdelani model smo preverili s testnimi spektri in neodvisnimi vzorci. NIR model smo preverili s specifičnostjo in robustnostjo. Bližnja infrardeča spektroskopija se je izkazala kot alternativna metoda klasičnim analiznim metodam. Bližnja infrardeča spektroskopija je enostavna za uporabo, hitra, nedestruktivna, okolju ter ljudem prijazna tehnika. Z njo prihranimo čas in zmanjšamo stroške reagentov.

Keywords

farmacevtske spojine;bližnja infrardeča spektroskopija;metoda grupiranja;kemometrijske metode;metoda glavnih osi;

Data

Language: Slovenian
Year of publishing:
Source: Maribor
Typology: 2.11 - Undergraduate Thesis
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: [B. Merkač]
UDC: 543.428.4(043.2)
COBISS: 13907990 Link will open in a new window
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Downloads: 380
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Other data

Secondary language: English
Secondary title: Chemometric characterization of pharmaceutical compounds using Near Infrared Spectroscopy
Secondary abstract: The scope of the research work was to develop NIR model for identification of different dried substances. Compounds saccharin sodium, microcrystalline cellulose, silicified microcrystalline cellulose, microcrystalline cellulose and carboxymethylcellulose sodium, crospovidone and carboxymethylcellulose sodium were analysed using NIR. The NIRS method developed implicated three types of NIRS methods: method design, development of statistical model and method validation. Each sample was recorded with reflection probe NIR spectra. Principal component analysis (PCA) was used for developing of NIR model. NIR model was tested for specificity and robustness. Near infrared spectroscopy has proven to be an alternative method to conventional methods of analysis. Near infrared spectroscopy is simple to use, fast and non-destructive analytical technique. It is environmental friendly technique. NIRS saves time of analyses and reduces the cost of reagents.
Secondary keywords: pharmaceutical compounds;near infrared spectroscopy;chemometrics methods;Principal Component Analysis;cluster method;
URN: URN:SI:UM:
Type (COBISS): Undergraduate thesis
Thesis comment: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages: VIII, 74 f.
Keywords (UDC): mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;analytical chemistry;analizna kemija;spectral analysis methods;optical analysis methods;
ID: 988667