John M. Hickey (Avtor), Gregor Gorjanc (Avtor)

Povzetek

An approach is described for simulating data sequence, genotype, and phenotype data to study genomic selection and genome-wide association studies (GWAS). The simulation method, implemented in a software package called AlphaDrop, can be used to simulate genomic data and phenotypes with flexibility in terms of the historical population structure, recent pedigree structure, distribution of quantitative trait loci effect, and with sequence and single nucleotide polymorphism-phased alleles and genotypes. Ten replicates of representative scenario used to study genomic selection in livestock were generated and have been made publically available. The simulated data sets were structured to encompass a spectrum of additive quantitative trait loci effect distributions, relastionship structures, and single nucleotide polymorpism chip densities.

Ključne besede

genomika;genomska selekcija;genotip;fenotip;simulacije;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.03 - Kratki znanstveni prispevek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 575
COBISS: 3034248 Povezava se bo odprla v novem oknu
ISSN: 2160-1836
Št. ogledov: 965
Št. prenosov: 467
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Neznan jezik
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 425-427
Letnik: ǂVol. ǂ2
Zvezek: ǂno. ǂ4
Čas izdaje: 2012
DOI: 10.1534/g3.111.001297
ID: 1033797