Franc Anderluh (Avtor), Ana Perpar (Avtor), Vaneja Velenik (Avtor), Irena Oblak (Avtor)

Povzetek

Karcinom požiralnika je relativno redka bolezen s slabo prognozo. Namen naše retrospektivne raziskave je bil oceniti različne načine in rezultate zdravljenja bolnikov z rakom požiralnika, ki so bili v obdobju od leta 2006 do 2010 obravnavani na Onkološkem inštitutu v Ljubljani (OIL). V raziskavo je bilo vključenih 151 bolnikov, od katerih jih je bilo 74 zdravljenih paliativno in 75 radikalno. Pri dveh bolnikih je bilo načrtovano radikalno zdravljenje, vendar sta zaradi zapletov s hitrim poslabšenjem splošnega stanja prejela le podporno zdravljenje. Petletno celokupno preživetje (CP) je za vse bolnike znašalo 9.5%, za zdravljene paliativno 0% in zdravljene radikalno 18.7%. Ustrezne vrednosti za petletno preživetje brez progresa bolezni (PBP) so bile za vse bolnike 22.4% in za zdravljene radikalno 29.6%. V skupini radikalno zdravljenih bolnikov je bila opravljena tudi primerjava preživetij med skupino 50 bolnikov, ki so bili zdravljeni samo z obsevanjem z ali brez sočasne kemoterapije in skupino 25 bolnikov, ki so bili pred ali po radio- in/ali kemoterapiji tudi operirani. Med podskupinama statistično pomembne razlike v CP (p=0.42) in v PBP (p=0.31) ni bilo. Rezultati zdravljenja teh bolnikov so v Sloveniji slabi, vendar ne odstopajo bistveno od prav tako slabih rezultatov iz raziskave EUROCARE-5. Odgovor na vprašanje ali bomo pri zdravljenju raka požiralnika z dosledno uporabo trimodalnega zdravljenja (pri izbranih bolnikih) in morebitno uporabo novih kemoterapevtskih shem dosegli kakršenkoli napredek, bodo lahko dale samo dobro načrtovane in izpeljane prospektivne raziskave .

Ključne besede

rak požiralnika;bolniki;zdravljenje;preživetje;

Podatki

Jezik: Slovenski jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: OI - Onkološki inštitut Ljubljana
UDK: 616.21
COBISS: 1962875 Povezava se bo odprla v novem oknu
ISSN: 1408-1741
Matična publikacija: Onkologija
Št. ogledov: 2400
Št. prenosov: 636
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarni naslov: Treatment results in patients with esophageal carcinoma treated at the Institute of oncology in Ljubljana from 2006–2010
Sekundarni povzetek: Esophageal carcinoma is a relatively rare disease with bad prognosis. The purpose of our retrospective study was to evaluate the methods and results of treatment of patients with esophageal cancer, who were treated at the Institute of Oncology in Ljubljana (OIL) from 2006 to 2010. The study included 151 patients, of whom 74 received palliative treatment and 75 radical treatment. In two patients radical treatment had been planned, but because of rapidly progressing complications and deteriorating general condition they only received supporting treatment. The five-year overall survival (OS) rate for all patients amounted to 9.5%, of those receiving palliative treatment 0% and those receiving radical treatment 18.7%. The corresponding values for five-year progression-free survival (PFS) rate were for all patients 22.4% and for radically treated patients 29.6%. In radically treated patients we also performed a survival comparison study between the group of 50 patients, who were treated only with radiation with or without simultaneous chemotherapy and the group of 25 patients, who had also been operated either prior or post radio and/ or chemotherapy. There were no significant differences among the subgroups in OS (p=0.42) or PFS (p=0.31). The results of treatment of these patients in Slovenia are poor, but do not substantially differ from the likely poor results from the EUROCARE-5 study. Whether consistent trimodality therapy in treating esophageal cancer (in selected patients) and potential use of new chemotherapeutic schemes can achieve any kind of progress, is a question, which only carefully planned and implemented prospective studies can answer.
URN: URN:NBN:SI
Strani: str. 84-88, 118
Letnik: ǂLetn. ǂ18
Zvezek: ǂšt. ǂ2
Čas izdaje: dec. 2014
ID: 10956193