Jana Brankovič (Avtor), Gregor Fazarinc (Avtor), Maja Antanasova (Avtor), Peter Jevnikar (Avtor), Janja Jan (Avtor), Ines Anders (Avtor), Katarina Pavšič Vrtač (Avtor), Breda Jakovac-Strajn (Avtor), David Antolinc (Avtor), Milka Vrecl (Avtor)

Povzetek

Exposure to polychlorinated biphenyls (PCBs), which are persistent lipophilic environmental pollutants, has a variety of adverse effects on wildlife and human health, including bone mineralization, growth and mechanical strength. The present study evaluated the effects of lactational exposure to nondioxin-like PCB-155 and dioxin-like PCB-169, individually and in combination, on pubertal rat femur development and its biomechanics. After offspring delivery, Wistar rat mothers were divided into four groups, i.e., PCB-169, PCB-155, PCB-155+169 and control, and were administered PCBs intraperitoneally. Data on bone geometry, biomechanics and mineral composition were obtained by analysis of femurs from 42-day-old offspring by microCT scanning, three-point bending test and inductively coupled plasma mass spectrometry. Decreased somatic mass and femur size, i.e., mass, periosteal circumference and cross sectional area, were observed in the PCB-169 and PCB-155 groups. Additionally, lactational exposure to planar PCB-169 resulted in harder and more brittle bones containing higher amounts of minerals. Combined exposure to structurally and functionally different PCBs demonstrated only mild alterations in bone width and mineralization. To conclude, our results demonstrated that alterations, observed on postnatal day 42, were primarily induced by PCB-169, while toxicity from both of the individual congeners may have been reduced in the combined group.

Ključne besede

polychlorinated biphenyls;bone;biochemical parameters;geometry;biomechanics;rats;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL VF - Veterinarska fakulteta
Založnik: Academic Press
UDK: 611
COBISS: 4812666 Povezava se bo odprla v novem oknu
ISSN: 0147-6513
Št. ogledov: 688
Št. prenosov: 268
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Polychlorinated Biphenyls;Bone and Bones;Biochemistry;Rats;
Vrsta dela (COBISS): Članek v reviji
Konec prepovedi (OpenAIRE): 2021-05-08
Strani: str. 106-113
Zvezek: ǂVol. ǂ180
Čas izdaje: 25 Apr. 2019
DOI: 10.1016/j.ecoenv.2019.04.076
ID: 11195996