Bartolome R. Celli (Avtor), Nicholas Locantore (Avtor), Ruth Tal-Singer (Avtor), John Riley (Avtor), Bruce E. Miller (Avtor), Jørgen Vestbo (Avtor), Julie C. Yates (Avtor), Edwin K Silverman (Avtor), Caroline A. Owen (Avtor), Miguel Divo (Avtor), Mitja Košnik (Sodelavec pri raziskavi)

Povzetek

We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments in 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort. Clinical and selected systemic biomarker measurements were compared in subjects grouped by quantitative tomography scan emphysema quartiles using the percentage of low attenuation area (LAA%). Lowest and highest quartile patients had amino-acid metabolomic profiles. We related LAA% to 3 years decline in lung function (forced expiratory volume in 1 s (FEV1)), body mass index (BMI), fat-free mass index (FFMI) and exacerbations, hospitalisations and mortality rates. Participants with more baseline emphysema had lower FEV1, BMI and FFMI, worse functional capacity, and less cardiovascular disease but more osteoporosis. Systemic C-reactive protein and interleukin-6 levels were similar among groups, but club cell protein 16 was higher and interleukin-8, surfactant protein D and soluble receptor for advanced glycation end product were lower with more emphysema. Metabolomics differed between extreme emphysema quartiles. Patients with more emphysema had accelerated FEV1, BMI and FFMI decline and more exacerbations, hospitalisations and mortality. COPD patients with more emphysema undergo excessive loss of pulmonary and extrapulmonary tissue, which is probably related to abnormal tissue maintenance. Because of worse clinical outcomes, we propose this subgroup be named the multi-organ loss of tissue (MOLT) COPD phenotype.

Ključne besede

COPD;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Založnik: European Respiratory Society
UDK: 616.2
COBISS: 2048254321 Povezava se bo odprla v novem oknu
ISSN: 1399-3003
Št. ogledov: 601
Št. prenosov: 221
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: KOPB;Pulmonary disease, chronic obstructive;Emphysema;Kronična obstruktivna pljučna bolezen;Emfizem;
Komentar vira: Soavtorji: Nicholas Locantore, Ruth Tal-Singer, John Riley, Bruce Miller, Jørgen Vestbo, Julie C. Yates, Edwin K. Silverman, Caroline A. Owen, Miguel Divo, Victor Pinto-Plata, Emiel F. M. Wouters, Rosa Faner and Alvar Agusti, on behalf of the ECLIPSE Study Investigators; Nasl. z nasl. zaslona; Opis vira z dne 7. 3. 2018;
Strani: str. 1-10
Letnik: ǂVol. ǂ51
Zvezek: ǂiss. ǂ2
Čas izdaje: Feb. 2018
DOI: 10.1183/13993003.02146-2017
ID: 12255941