Iron-binding and anti-fenton properties of novel amino acid-derived cyclic imide dioximes

Janez Mravljak (Avtor), Žiga Jakopin (Avtor)

Povzetek

We present a novel route for the preparation of amino acid-derived cyclic imide dioxime derivatives. Readily accessible amino acids were conveniently converted to their corresponding cyclic imide dioximes in simple synthetic steps. The aim of this work was to describe and compare the iron-chelating and antioxidant properties of synthesized compounds in relation to their molecular structure, and in particular, which of those features are essential for iron(II)-chelating ability. The glutarimide dioxime moiety has been established as an iron(II)-binding motif and imparts potent anti-Fenton properties to the compounds. Compound 3 was shown to strongly suppress hydroxyl radical formation by preventing iron cycling via Fe-complexation. These findings provide insights into the structural requirements for achieving anti-Fenton activity and highlight the potential use of glutarimide dioximes as antioxidants.

Ključne besede

amino acid;building block;iron(II)-chelating agents;cyclic imide dioxime;antioxidant;Fenton reaction;anti-Fenton;

Podatki

Jezik:	Angleški jezik
Leto izida:	2019
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL FFA - Fakulteta za farmacijo
Založnik:	MDPI
UDK:	547.466:615.4:54
COBISS:	4819569
ISSN:	2076-3921
Št. ogledov:	340
Št. prenosov:	161
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	Aminokisline;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-12
Letnik:	ǂVol. ǂ8
Zvezek:	ǂiss. ǂ10
Čas izdaje:	2019
DOI:	10.3390/antiox8100473
ID:	12642517