Marcos Gouveia (Avtor), Hiroko Ikeshima-Kataoka (Avtor), Špela Zemljič Jokhadar (Avtor), Marko Vidak (Avtor), Biljana Stojković (Avtor), Jure Derganc (Avtor), Rui Travasso (Avtor), Mirjana Liović (Avtor)

Povzetek

Keratins are one of the most abundant proteins in epithelial cells. They form a cytoskeletal filament network whose structural organization seriously conditions its function. Dynamic keratin particles and aggregates are often observed at the periphery of mutant keratinocytes related to the hereditary skin disorder epidermolysis bullosa simplex, which is due to mutations in keratins 5 and 14. To account for their emergence in mutant cells, we extended an existing mathematical model of keratin turnover in wild-type cells and developed a novel 2D phase-field model to predict the keratin distribution inside the cell. This model includes the turnover between soluble, particulate and filamentous keratin forms. We assumed that the mutation causes a slowdown in the assembly of an intermediate keratin phase into filaments, and demonstrated that this change is enough to account for the loss of keratin filaments in the cell's interior and the emergence of keratin particles at its periphery. The developed mathematical model is also particularly tailored to model the spatial distribution of keratins as the cell changes its shape.

Ključne besede

keratin;epidermoliza bullosa simplex;mutacija;epidermolysis bullosa simplex;mutation;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 61
COBISS: 34772697 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 374
Št. prenosov: 145
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: keratin;epidermoliza bullosa simplex;mutacija;model faznega polja;enačba reakcije-difuzije-advekcije;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-13
Letnik: ǂVol. ǂ21
Zvezek: ǂiss. ǂ7
Čas izdaje: 2020
DOI: 10.3390/ijms21072596
ID: 12717700