from model membranes to living organisms
Luka Kristanc (Avtor), Bojan Božič (Avtor), Špela Zemljič Jokhadar (Avtor), Marija Sollner Dolenc (Avtor), Gregor Gomišček (Avtor)

Povzetek

The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.

Ključne besede

polyenes;sterols;pore forming;tension pore;osmotic stress;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL ZF - Zdravstvena fakulteta
UDK: 579+616
COBISS: 4634737 Povezava se bo odprla v novem oknu
ISSN: 0005-2736
Št. ogledov: 339
Št. prenosov: 85
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: polieni;steroli;tvorjenje por;tenzijska pora;osmotski stres;Patogeni;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 418-430
Letnik: ǂVol. ǂ1861
Zvezek: ǂiss. ǂ2
Čas izdaje: 2019
DOI: 10.1016/j.bbamem.2018.11.006
ID: 13181188