Špela Borštnar (Avtor), Željka Večerić-Haler (Avtor), Emanuela Boštjančič (Avtor), Živa Pipan Tkalec (Avtor), Damjan Kovač (Avtor), Jelka Lindič (Avtor), Nika Kojc (Avtor)

Povzetek

Uromodulin and microRNAs (miRNAs) have recently been investigated as potential biomarkers for kidney graft associated pathology and outcome, with a special focus on biomarkers indicating specific disease processes and kidney graft survival. The study's aim was to determine whether expression of serum uromodulin concentration and selected miRNAs might be related to renal function in kidney transplant recipients (KTRs). The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. Kidney graft function was estimated with routine parameters (creatinine, urea, cystatin C, and Chronic Kidney Disease Epidemiology Collaboration study equations) and precisely measured using chromium-51 labelled ethylenediaminetetraacetic-acid clearance. The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected functioning tubules rather than any specific kidney graft injury. However, decreased concentrations of serum uromodulin can be observed in the early course of tubulo interstitial injury, there by suggesting its useful role as an accurate, noninvasive biomarker of early (subclinical) kidney graft injury.

Ključne besede

mikroRNA;uromodulin;delovanje ledvičnega presadka;biološki označevalec;presaditev ledvic;microRNA;kidney graft function;biomarker;kidney transplantation;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.6
COBISS: 24550915 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 346
Št. prenosov: 89
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: mikroRNA;uromodulin;delovanje ledvičnega presadka;biološki označevalec;presaditev ledvic;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-11
Letnik: ǂVol. ǂ21
Zvezek: ǂiss. ǂ16
Čas izdaje: 2020
DOI: 10.3390/ijms21165592
ID: 13188522