Maša Mavri (Avtor), Katja Spiess (Avtor), Mette Marie Rosenklide (Avtor), Catrin Rutland (Avtor), Milka Vrecl (Avtor), Valentina Kubale (Avtor)

Povzetek

Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled receptors (GPCRs) constitute a family of receptors with seven transmembrane alpha-helical domains (7TM receptors) expressed at the cell surface, where they regulate physiological and pathological cellular processes. Several herpesviruses encode receptors (vGPCRs) which benefits the virus by avoiding host immune surveillance, supporting viral dissemination, and thereby establishing widespread and lifelong infection, processes where receptor signaling and/or endocytosis seem central. vGPCRs are rising as potential drug targets as exemplified by the cytomegalovirus-encoded receptor US28, where its constitutive internalization has been exploited for selective drug delivery in virus infected cells. Therefore, studying GPCR trafficking is of great importance. This review provides an overview of the current knowledge of endocytic and cell localization properties of vGPCRs and methodological approaches used for studying receptor internalization. Using such novel approaches, we show constitutive internalization of the BILF1 receptor from human and porcine γ-1 herpesviruses and present motifs from the eukaryotic linear motif (ELM) resources with importance for vGPCR endocytosis.

Ključne besede

endocytosis;G-protein coupled receptors;herpesvirus;methods;Herpesviridae;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL VF - Veterinarska fakulteta
UDK: 636.09:616
COBISS: 40808963 Povezava se bo odprla v novem oknu
ISSN: 1420-3049
Št. ogledov: 293
Št. prenosov: 76
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Endocytosis;Receptors, G-Protein-Coupled;Herpesviridae;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-23
Letnik: ǂVol. ǂ25
Zvezek: ǂno. ǂ23
Čas izdaje: 2020
DOI: 10.3390/molecules25235710
ID: 13207953