Maja Potokar (Avtor), Nina Vardjan (Avtor), Matjaž Stenovec (Avtor), Mateja Gabrijel (Avtor), Saša Trkov (Avtor), Jernej Jorgačevski (Avtor), Marko Kreft (Avtor), Robert Zorec (Avtor)

Povzetek

Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions.

Ključne besede

glia;astrocytes;multiple sclerosis;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616-092
COBISS: 30620377 Povezava se bo odprla v novem oknu
ISSN: 1661-6596
Št. ogledov: 480
Št. prenosov: 133
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: glija;astrociti;multipla skleroza;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 11238-11258
Letnik: ǂVol. ǂ14
Zvezek: ǂiss. ǂ6
Čas izdaje: 2013
DOI: 10.3390/ijms140611238
ID: 13299919