Patrícia Kimáková (Avtor), Peter Solár (Avtor), Zuzana Solárová (Avtor), Radovan Komel (Avtor), Nataša Debeljak (Avtor)

Povzetek

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth factor that exhibits growth stimulation and cell/tissue protection on numerous cells and tissues. In this article we review the angiogenesis potential of EPO on endothelial cells in heart, brain, and leg ischemia, as well as its role in retinopathy protection and tumor promotion. Furthermore, the effect of EPO on bone marrow and adipose tissue is also discussed.

Ključne besede

eritropoetin;receptor eritropoetina;rak;erythropoietin;erythropoietin receptor;cancer;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616-006
COBISS: 33325785 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 170
Št. prenosov: 58
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: eritropoetin;receptor eritropoetina;rak;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-14
Letnik: ǂVol. ǂ18
Zvezek: ǂiss. ǂ7
Čas izdaje: Jul. 2017
DOI: 10.3390/ijms18071519
ID: 13518212