Alexander A. Mironov (Avtor), Anna Mironov (Avtor), Jure Derganc (Avtor), Galina V Beznoussenko (Avtor)

Povzetek

In biology, the modern scientific fashion is to mostly study proteins. Much less attention is paid to lipids. However, lipids themselves are extremely important for the formation and functioning of cellular membrane organelles. Here, the role of the geometry of the lipid bilayer in regulation of organelle shape is analyzed. It is proposed that during rapid shape transition, the number of lipid heads and their size (i.e., due to the change in lipid head charge) inside lipid leaflets modulates the geometrical properties of organelles, in particular their membrane curvature. Insertion of proteins into a lipid bilayer and the shape of protein trans-membrane domains also affect the trans-membrane asymmetry between surface areas of luminal and cytosol leaflets of the membrane. In the cases where lipid molecules with a specific shape are not predominant, the shape of lipids (cylindrical, conical, or wedge-like) is less important for the regulation of membrane curvature, due to the flexibility of their acyl chains and their high ability to diffuse.

Ključne besede

zlitje mitohondrijev;asimetrija transmembranskega območja;cepitev membrane;mitochondria fusion;trans-membrane area asymmetry;membrane fission;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 577
COBISS: 72994307 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 129
Št. prenosov: 45
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: zlitje mitohondrijev;asimetrija transmembranskega območja;cepitev membrane;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-19
Letnik: ǂVol. ǂ21
Zvezek: ǂno. ǂ20
Čas izdaje: 2020
DOI: 10.3390/ijms21207594
ID: 14271474