Vito Kovač (Avtor), Borut Poljšak (Avtor), Jasmina Primožič (Avtor), Polona Jamnik (Avtor)

Povzetek

Compositions of stainless steel, nickel-titanium, cobalt-chromium and β-titanium orthodontic alloys were simulated with mixtures of Fe, Ni, Cr, Co, Ti and Mo metal ions as potential oxidative stress-triggering agents. Wild-type yeast Saccharomyces cerevisiae and two mutants ∆Sod1 and ∆Ctt1 were used as model organisms to assess the cytotoxicity and oxidative stress occurrence. Metal mixtures at concentrations of 1, 10, 100 and 1000 µM were prepared out of metal chlorides and used to treat yeast cells for 24 h. Every simulated orthodontic alloy at 1000 µM was cytotoxic, and, in the case of cobalt-chromium alloy, even 100 µM was cytotoxic. Reactive oxygen species and oxidative damage were detected for stainless steel and both cobalt-chromium alloys at 1000 µM in wild-type yeast and 100 µM in the ∆Sod1 and ∆Ctt1 mutants. Simulated nickel-titanium and β-titanium alloy did not induce oxidative stress in any of the tested strains.

Ključne besede

ortodontski pripomočki;kovinski ioni;kvasovke;citotoksičnost;oksidativni stres;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 616.314-089.23:546.73/.76:549.261/.263:582.283.23
COBISS: 34996227 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 147
Št. prenosov: 50
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: ortodontski pripomočki;kovinski ioni;kvasovke;citotoksičnost;oksidativni stres;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-16
Letnik: ǂVol. ǂ21
Zvezek: ǂiss. ǂ21
Čas izdaje: 2020
DOI: 10.3390/ijms21217993
ID: 14373105