Biocompatible nanomaterials

synthesis, characterization and applications

Maja Leitgeb (Avtor), Mateja Primožič (Avtor), Željko Knez (Avtor)

Povzetek

Nanotechnology represents an area holding significant promise for health care and biotechnology for many years to come. Nanomaterials are an emerging familyof novel materials that could be designed for specific properties. Thesematerials will probably bring about significant shifts in the manner we design, develop, and use materials. With the emergence of novel fabrication and characterization technologies, new combinations of nanomaterials or nanocomposites are beginning to be synthesized and characterized. They have potential for various biomedical applications; including magnetic resonance imaging (MRI) contrast enhancement, targeted drug delivery, hyperthermia, biological separation, protein immobilization, biosensors, etc. The use of magnetic carriers for efficient transport of various biomolecules (e.g. antibody, enzyme) has increased drastically in the recent years, especially inthe field of nanomedicine, where the bioactive molecule immobilized onto thesurface of a magnetic carrier acts a potential bioactive substance or drug to be transported and effectively released in the specific location. In this direction, superparamagnetic iron oxide nanoparticles (SPIONs) with appropriate surface chemistry have been widely used experimentally for numerous applications. In past decades, many carriers have been developed and investigated extensively, but mostly the group of chemically modified inorganic nanoparticles have showed low toxicity and generally possess versatile properties suitable for cellular delivery, including wide availability, rich functionality, good biocompatibility, potential capability of targeted delivery and controlled released of carried drugs. Because surfacechemistry greatly influences magnetic nanoparticles (MNPs) fate in the biological system, including the mechanisms of their cell recognition, biodistribution and immunes response it presents a specific focus for advancing engineering strategies to minimize potential nanotoxicity. Surface functionalization, a controlled process of chemical attachment of functional groups to the surface, is now integral to magnetic nanoparticle designs. Moreover, surface chemistry is essential to target the nanoparticles to specific sites. Several groups of coating materials are generally used to modify magnetic nanoparticle surface chemistry. Additionally, one of the most attractive routes for the surface modification of nanoparticles is using an organosilane. The biocompatibility of most nanoparticles could be greatly enhanced by introducing various synthetic polymers to their surface, thus, promoting better water solubility of the magnetic carrier. Silica is also one of the most frequently functional coatings used so far, as it has inherently superior functionalization capabilities, respectively. For these reasons, overthe last decade, nanomaterials have been highlighted as promising candidates for improving traditional materials.

Ključne besede

nanaomateriali;sinteza;aplikacije;karakterizacija;

Podatki

Jezik:	Angleški jezik
Leto izida:	2012
Tipologija:	1.16 - Samostojni znanstveni sestavek ali poglavje v monografski publikaciji
Organizacija:	UM FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK:	66.098:579
COBISS:	16159766
Št. ogledov:	47376
Št. prenosov:	29
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Neznan jezik
URN:	URN:SI:UM:
Vrsta dela (COBISS):	Delo ni kategorizirano
Strani:	Str. 135-156
ID:	1439103