from molecular mechanisms to potential clinical implications
Mojca Jensterle Sever (Avtor), Manfredi Rizzo (Avtor), Andrej Janež (Avtor)

Povzetek

Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.

Ključne besede

glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;glucagon-like peptide 1 (GLP-1);taste;tongue;obesity;sweet;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.379
COBISS: 47378691 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 164
Št. prenosov: 43
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: glukagonu podoben peptid 1 (GLP-1);okus;jezik;debelost;sladko;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-13
Letnik: ǂVol. ǂ22
Zvezek: ǂiss. ǂ2
Čas izdaje: 2021
DOI: 10.3390/ijms22020902
ID: 14527786