Aljaž Velikonja (Avtor), Poornima Budime Santhosh (Avtor), Ekaterina Gongadze (Avtor), Mukta Vishwanath Kulkarni (Avtor), Kristina Eleršič (Avtor), Šárka Perutková (Avtor), Veronika Kralj-Iglič (Avtor), Nataša Poklar Ulrih (Avtor), Aleš Iglič (Avtor)

Povzetek

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

Ključne besede

biološke membrane;biofizika membrane;lipidi;nanodelci;elektrostatske interakcije;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FE - Fakulteta za elektrotehniko
UDK: 577.352:576.314
COBISS: 4257144 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 1105
Št. prenosov: 324
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: biološke membrane;biofizika membrane;lipidi;nanodelci;elektrostatske interakcije;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 15312-15329
Letnik: ǂVol. ǂ14
Zvezek: ǂno. ǂ8
Čas izdaje: 2013
DOI: 10.3390/ijms140815312
ID: 1478040