Small prokaryotic DNA-binding proteins protect genome integrity throughout the life cycle

Katja Molan (Avtor), Darja Žgur-Bertok (Avtor)

Povzetek

Genomes of all organisms are persistently threatened by endogenous and exogenous assaults. Bacterial mechanisms of genome maintenance must provide protection throughout the physiologically distinct phases of the life cycle. Spore-forming bacteria must also maintain genome integrity within the dormant endospore. The nucleoid-associated proteins (NAPs) influence nucleoid organization and may alter DNA topology to protect DNA or to alter gene expression patterns. NAPs are characteristically multifunctional; nevertheless, Dps, HU and CbpA are most strongly associated with DNA protection. Archaea display great variety in genome organization and many inhabit extreme environments. As of yet, only MC1, an archaeal NAP, has been shown to protect DNA against thermal denaturation and radiolysis. ssDNA are intermediates in vital cellular processes, such as DNA replication and recombination. Single-stranded binding proteins (SSBs) prevent the formation of secondary structures but also protect the hypersensitive ssDNA against chemical and nuclease degradation. Ionizing radiation upregulates SSBs in the extremophile Deinococcus radiodurans.

Ključne besede

DNA protection;nucleoid-associated proteins;small acid soluble proteins;single-stranded DNA-binding proteins;

Podatki

Jezik:	Angleški jezik
Leto izida:	2022
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	579.25:575.111
COBISS:	103764739
ISSN:	1422-0067
Št. ogledov:	40
Št. prenosov:	27
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	molekularna genetika;genom;DNA;proteini;
Vrsta dela (COBISS):	Znanstveno delo
Strani:	str. 1-15, art. 4008
Letnik:	ǂVol. ǂ23
Zvezek:	ǂiss. ǂ7
Čas izdaje:	2022
DOI:	10.3390/ijms23074008
ID:	15664335