Miha Tibaut (Avtor), Franjo Naji (Avtor), Danijel Petrovič (Avtor)

Povzetek

Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.

Ključne besede

sladkorna bolezen tip 2;miokardni infarkt;bolezen koronarnih arterij;type 2 diabetes mellitus;myocardial infarction;coronary artery disease;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.1
COBISS: 102534915 Povezava se bo odprla v novem oknu
ISSN: 2073-4425
Št. ogledov: 63
Št. prenosov: 23
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: sladkorna bolezen tip 2;miokardni infarkt;bolezen koronarnih arterij;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-8
Letnik: ǂVol. ǂ13
Zvezek: ǂiss. ǂ3
Čas izdaje: 2022
DOI: 10.3390/genes13030526
ID: 15702043