Ajda Anžič Drofenik (Avtor), Matjaž Vrtovec (Avtor), Mojca Božič (Avtor), Matjaž Sever (Avtor), Irena Preložnik-Zupan (Avtor), Nataša Kejžar (Avtor), Aleš Blinc (Avtor)

Povzetek

Background and aims: Patients with myeloproliferative neoplasms often succumb to cardiovascular events, but little is known on the early stages of their vascular disease. We studied how patients with JAK2 V617F positive essential thrombocythemia (ET) without overt atherosclerotic disease differed from control subjects in the progression of carotid artery stiffness and preclinical atherosclerosis. Methods: Thirty-six patients with JAK2 V617F positive ET and 38 age-, gender- and Framingham coronary heart disease (CHD) -matched control subjects were examined twice within 4 years. Clinical and laboratory testing, echo-tracking ultrasound of carotid arteries, coronary calcium measurement and digital plethysmography were performed (ClinTrials.gov NCT03828422). Results: Coronary calcium correlated with the Framingham CHD risk score at the first examination in the control group (r$_s$ = 0.410), but not among the ET patients (r$_s$ = 0.116). Both groups progressed in coronary calcium, but the outliers were more prominent among ET patients. Carotid artery stiffness increased with time in the ET patients much more than in the control group: the increase in β-index 1.95 (SD 2.18) vs. 0.22 (SD 1.99), p < 0.001, and the increase in carotid pulse wave velocity 0.72 (SD 0.92) vs. 0.08 (SD 0.72) m/s, p = 0.001. There was no correlation between carotid stiffness and Framingham CHD risk in either group. Digital endothelial function did not change. Conclusion: Carotid artery stiffness progressed faster in patients with JAK2 V617F positive ET than in control subjects. Coronary calcium correlated with the Framingham CHD risk only in control subjects. This indicates that JAK2 V617F positive ET acted as a non-classical risk factor for vascular disease.

Ključne besede

essential thrombocythemia;JAK2 V617F mutation;arterial stiffness;coronary calcium;cardiovascular risk;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.1
COBISS: 6959276 Povezava se bo odprla v novem oknu
ISSN: 0021-9150
Št. ogledov: 49
Št. prenosov: 29
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Vrsta dela (COBISS): Članek v reviji
Strani: str. 25-31
Zvezek: ǂVol. ǂ286
Čas izdaje: Mar. 2020
DOI: 10.1016/j.atherosclerosis.2020.01.001
ID: 15786521