Črt Dragar (Avtor), Nives Ileršič (Avtor), Tanja Potrč (Avtor), Sebastjan Nemec (Avtor), Slavko Kralj (Avtor), Petra Kocbek (Avtor)

Povzetek

One of the key technological challenges in the development of iron-oxide-based magnetic nanoparticles (MNPs) is their long-term physical stability in colloidal dispersions. This can be improved by their transformation into a dry form. Here, we introduce electrospinning as a drying method for ethanol-based and water-based MNP dispersions, which enables the preparation of high-loaded dry MNP products. The obtained easily dispersible electrospun product contained up to 50 % (w/w) of MNPs, homogeneously distributed in the fibrillar structure, which is much more compared to the products of currently available methods for drying MNP dispersions. The polymers used as building blocks of nanofibers, namely poloxamer 188 and polyethylene oxide, improved the tolerance of MNPs to high ionic strength dispersion medium and thus enhanced the short-term physical stability of MNP dispersions after reconstitution. The dry product was stable for up to 1 month at room temperature and relative humidity up to 70 %. It was in the form of a nanofiber mat, which prevented the aerosolization of MNPs and their unintentional ambient exposure. Therefore, the electrospun product with MNPs is expected to be a safer dry formulation of MNPs than the nanoparticulate powders, which are usually the final products of the conventional drying methods.

Ključne besede

drying;electrospinning;magnetic nanoparticles;nanofibers;physical stability;Poloxamer 188;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 537
COBISS: 130650883 Povezava se bo odprla v novem oknu
ISSN: 0378-5173
Št. ogledov: 69
Št. prenosov: 24
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: sušenje;elektropredenje;magnetni nanodelci;fizikalna stabilnost;Poloksamer 188;Nanovlakna;
Vrsta dela (COBISS): Članek v reviji
Strani: 16 str.
Letnik: Art. 122389
Zvezek: ǂVol. ǂ628
Čas izdaje: 2022
DOI: 10.1016/j.ijpharm.2022.122389
ID: 17653626