Neža Žnidaršič (Avtor), Malan Štrbenc (Avtor), Neža Grgurevič (Avtor), Tomaž Snoj (Avtor)

Povzetek

The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes that enable the hydrolysis of acetylcholine and in this way ensure homeostasis in cholinergic synapses. Cholinesterase inhibitors (ChEi) are a group of indirect-acting cholinergic agonists that influence the activity of the cholinergic system. Several compounds that can inhibit cholinesterases are of importance to veterinary medicine from pharmacological and toxicological perspective. The frequency of their use in veterinary medicine has fluctuated over the years and is now reduced to a minimum. They are mainly used in agriculture as pesticides, and some are rarely used as parasiticides for companion animals and livestock. In recent years, interest in the use of new cholinesterase inhibitors has increased since canine cognitive dysfunction (CCD) became a recognized and extensively studied disease. Similar to Alzheimer’s disease (AD) in humans, CCD can be treated with cholinesterase inhibitors that cross the blood–brain barrier. In this review, the mammalian cholinergic system and the drugs that interact with cholinesterases are introduced. Cholinesterase inhibitors that can be used for the treatment of CCD are described in detail.

Ključne besede

cholinergic system;cholinesterase inhibitors;organophosphates;carbamates;canine cognitive dysfunction;cognitive dysfunction;dogs;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL VF - Veterinarska fakulteta
UDK: 636.09:577:612
COBISS: 144140035 Povezava se bo odprla v novem oknu
ISSN: 2297-1769
Št. ogledov: 314
Št. prenosov: 54
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Cholinesterase Inhibitors;Organophosphates;Carbamates;Cognitive Dysfunction;Dogs;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-11
Zvezek: ǂVol. ǂ10, [article no.] 1125618
Čas izdaje: 2023
DOI: 10.3389/fvets.2023.1125618
ID: 18177096