Teja Brezovar (Avtor), Grega Hudovornik (Avtor), Matjaž Perpar (Avtor), Matevž Luštrik (Avtor), Rok Dreu (Avtor)

Povzetek

The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments, the pellet cores were coated with the Tartrazine dye with the aim of estimating the coating equipment performance in terms of coating thickness distribution, assessed through color hue. In the second set, drug-layered pellets were film-coated with prolonged-release coating and dissolution profile tests were performed to estimate the thickness and uniformity of the coating thickness among differently sized pellets. In both study parts, film coating was performed at the laboratory and the pilot scale and essentially two types of distribution plate and different height adjustments of the draft tube were compared. The dye coating study proved to be extremely useful, as the results enable process correction and the optimal use of the process equipment in combination with the appropriate process parameters. Preferential film coating of larger drug-containing pellets was confirmed on the laboratory scale, while on the pilot scale, it was possible to achieve preferential coating of smaller pellets using rational alternatives of settings, which is desirable in terms of particle size-independent drug release profile of such prolonged-release dosage forms.

Ključne besede

pellet film coating;Wurster chamber;swirl generator;prolonged release;preferential coating;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
UDK: 615.45:661.12
COBISS: 147500291 Povezava se bo odprla v novem oknu
ISSN: 1530-9932
Št. ogledov: 28
Št. prenosov: 10
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: peletna filmska prevleka;Wursterjeva komora;vrtinčni generator;podaljšano sproščanje;prednostna prevleka;Farmacevtska tehnologija;Farmacevtske oblike;
Vrsta dela (COBISS): Članek v reviji
Strani: 16 str.
Letnik: ǂVol. ǂ24
Zvezek: ǂiss. ǂ4, art. 93
Čas izdaje: 2023
DOI: 10.1208/s12249-023-02540-9
ID: 18476512