Adrenal vein sampling for primary aldosteronism

ǂa ǂ15-year national referral center experience

Tomaž Kocjan (Avtor), Mojca Jensterle Sever (Avtor), Gaj Vidmar (Avtor), Rok Vrčkovnik (Avtor), Pavel Berden (Avtor), Milenko Stankovič (Avtor)

Povzetek

Background Adrenal vein sampling (AVS) is essential for diagnostics of primary aldosteronism, distinguishing unilateral from bilateral disease and determining treatment options. We reviewed the performance of AVS for primary aldosteronism at our center during first 15 years, comparing the initial period to the period after the introduction of a dedicated radiologist. Additionally, AVS outcomes were checked against CT findings and the proportion of operated patients with proven unilateral disease was estimated. Patients and methods A retrospective cross-sectional study conducted at the national endocrine referral center included all patients with primary aldosteronism who underwent AVS after its introduction in 2004 until the end of 2018. AVS was performed sequentially during Synacthen infusion. When the ratio of cortisol concentrations from adrenal vein and inferior vena cava was at least 5, AVS was considered successful. Results Data from 235 patients were examined (168 men; age 32%73, median 56 years; BMI 18%48, median 30.4 kg/ m2). Average number of annual AVS procedures increased from 7 in the 2004%2011 period to 29 in the 2012%2018 period (p < 0.001). AVS had to be repeated in 10% of procedures; it was successful in 77% of procedures and 86% of patients. The proportion of patients with successful AVS (92% in 2012%2018 vs. 66% in 2004%2011, p < 0.001) and of successful AVS procedures (82% vs. 61%, p < 0.001) was statistically significantly higher in the recent period. Conclusions Number of AVS procedures and success rate at our center increased over time. Introduction of a dedicated radiologist and technical advance expanded and improved the AVS practice.

Ključne besede

angiography;adrenal gland;endocrine disorders;

Podatki

Jezik:	Angleški jezik
Leto izida:	2020
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	OI - Onkološki inštitut Ljubljana
Založnik:	Association of Radiology and Oncology
UDK:	616.4
COBISS:	27351043
ISSN:	1318-2099
Št. ogledov:	46
Št. prenosov:	25
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	angiografija;nadledvična žleza;endokrine motnje;
Komentar vira:	Soavtorji: Mojca Jensterle, Gaj Vidmar, Rok Vrckovnik, Pavel Berden and Milenko Stankovic;
Strani:	str. 409-418, III
Letnik:	ǂVol. ǂ54
Zvezek:	ǂno. ǂ4
Čas izdaje:	2020
DOI:	10.2478/raon-2020-0052
ID:	24531084