Hana Šinkovec (Avtor), Paul A. Kyrle (Avtor), Lisbeth Eischer (Avtor), Paul Gressenberger (Avtor), Thomas Gary (Avtor), Marianne Brodmann (Avtor), Georg Heinze (Avtor), Sabine Eichinger (Avtor)

Povzetek

Background: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation. Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE). Methods and Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.5% at 1 year for a median of 13.5 months. Their median age was 56 years, and 96% were men. After the VPM risk assessment, 196 patients restarted anticoagulation. While on anticoagulation, none of the patients experienced recurrent VTE, whereas 4 patients had nonmajor clinically relevant bleeding (absolute bleeding rate, 1.8 [95% CI, 0.5-4.5] events per 100 patient-years). Seventy patients were left untreated after VPM risk assessment for various reasons. Among patients not using anticoagulation, 15 had recurrence (absolute recurrence rate, 18.1 [95% CI, 10.1, 29.9] events per 100 person-years). According to the extended Kaplan–Meier analysis, the probability of VTE recurrence in patients not on anticoagulation was 10.1% and 17.9% at 6 and 12 months after VPM risk assessment, respectively. Conclusion: Anticoagulant therapy is effective and safe in patients with an unprovoked VTE, in whom the VPM had predicted a high risk of recurrent VTE. If these patients are left untreated, the risk of recurrence is high.

Ključne besede

deep vein thrombosis;pulmonary embolism;venous thromboembolism;Vienna Prediction Model recurrence;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 616.1
COBISS: 221026307 Povezava se bo odprla v novem oknu
ISSN: 2475-0379
Št. ogledov: 21
Št. prenosov: 17
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: globoka venska tromboza;pljučna embolija;venska trombembolija;
Vrsta dela (COBISS): Članek v reviji
Strani: 6 str.
Letnik: ǂVol. ǂ9
Zvezek: ǂissue ǂ1, [article no.] 102649
Čas izdaje: Jan. 2025
DOI: 10.1016/j.rpth.2024.102649
ID: 25639371