On zinc(II) coordination chemistry with furosemide
ǂa ǂjourney from a mononuclear complex to a coordination polymer
Povzetek
In continuation of our studies on zinc(II) coordination chemistry, reactions between the zinc(II) starting material and furosemide were investigated. Furosemide, a well-known pharmaceutical, contains functional groups which could serve as donors in coordination with metal ions. Reactions between zinc oxide or chloride and furosemide in aqueous ammonia solution yielded a mononuclear complex, [Zn(NH$_3$)$_2$(fur)$_2$] (1), where fur− stands for deprotonated furosemide. Unfortunately, some reactions produced mixtures of the desired metal complex 1 and by-product, ammonium salt NH$_4$fur (2). To further explore the coordination chemistry of furosemide, quinaldinate (an anion of quinoline-2-carboxylic acid, abbreviated as quin$^−$) was introduced into the reaction system, resulting in the formation of a coordination polymer, [Zn$_3$(quin)$_4$(fur)$_2$]$_n$·2nCH$_3$OH (3). 1 and 3 were evaluated for their antibacterial properties against Gram-positive and Gram-negative bacteria. Notably, compound 3 exhibited moderate antibacterial activity against Staphylococcus epidermidis, representing a promising starting point for the preparation of potential antibacterial zinc(II) complexes.
Ključne besede
furosemid;kinaldinat;cink(II);koordinacijske spojine;polimer;kristalna struktura;antibakterijska aktivnost;furosemide;quinaldinate;zinc(II);coordination compounds;polymer;crystal structure;antibacterial activity;
Podatki
| Jezik: | Angleški jezik |
|---|---|
| Leto izida: | 2025 |
| Tipologija: | 1.01 - Izvirni znanstveni članek |
| Organizacija: | UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo |
| UDK: | 546.47 |
| COBISS: |
238212611
|
| ISSN: | 1369-9261 |
| Št. ogledov: | 183 |
| Št. prenosov: | 46 |
| Ocena: | 0 (0 glasov) |
| Metapodatki: |
|
Ostali podatki
| Sekundarni jezik: | Slovenski jezik |
|---|---|
| Sekundarne ključne besede: | furosemid;kinaldinat;cink(II);koordinacijske spojine;polimer;kristalna struktura;antibakterijska aktivnost; |
| Vrsta dela (COBISS): | Članek v reviji |
| Strani: | str. 9113-9122 |
| Letnik: | ǂVol. ǂ49 |
| Zvezek: | ǂiss. ǂ22 |
| Čas izdaje: | 14 Jun. 2025 |
| DOI: | 10.1039/D5NJ01438G |
| ID: | 26525961 |
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