diplomsko delo
Povzetek
patogenih mikroorganizmov in prispevajo k zdravju gostitelja. Najpogosteje preučevani
so predstavniki iz rodov Lactobacillus in Bifidobacterium, ki se pogosto uporabljajo v
fermentiranih živilih in prehranskih dopolnilih. Med najpomembnejšimi mehanizmi
delovanja probiotikov so sinteza protimikrobnih spojin (bakteriocini, vodikov peroksid,
organske kisline), kompeticija za adhezijska mesta in hranila na črevesnem epiteliju,
izboljšava črevesne epitelne pregrade, uravnavanje sinteze nevrotransmiterjev in
signalne poti osi črevesje–možgani ter imunomodulacija. Čeprav je pozitiven vpliv
probiotikov na zdravje gostitelja precej raziskan, številni mehanizmi na molekularni
ravni še vedno niso v celoti pojasnjeni. Nadaljnje raziskave so nujne za boljše
razumevanje teh procesov in razvoj učinkovitih alternativ pri preprečevanju in
zdravljenju okužb. Pomen probiotikov se v tem kontekstu povečuje, saj je neustrezna
uporaba antibiotikov privedla do naraščajoče ravni odpornosti mikroorganizmov proti
antibiotikom.
Ključne besede
bioaktivne snovi;probiotik;mehanizem delovanja;Lactobacillus spp.;Bifidobacterium spp.;protimikrobna spojina;konkurenčna izključitev;epitelna pregrada;imunomodulacija;
Podatki
| Jezik: |
Slovenski jezik |
| Leto izida: |
2025 |
| Tipologija: |
2.11 - Diplomsko delo |
| Organizacija: |
UL BF - Biotehniška fakulteta |
| Založnik: |
[H. Hadžić] |
| UDK: |
602.3(043.2) |
| COBISS: |
246439171
|
| Št. ogledov: |
99 |
| Št. prenosov: |
14 |
| Ocena: |
0 (0 glasov) |
| Metapodatki: |
|
Ostali podatki
| Sekundarni jezik: |
Angleški jezik |
| Sekundarni naslov: |
Mechanisms of probiotics action for the control of pathogenic microorganisms |
| Sekundarni povzetek: |
This diploma thesis focuses on the mechanisms by which probiotics inhibit the growth
of pathogenic microorganisms and contribute to host health. The most commonly
studied representatives belong to the genera Lactobacillus and Bifidobacterium, which
are widely used in fermented foods and dietary supplements. The most important
mechanisms of action include the synthesis of antimicrobial substances (i.e.,
bacteriocins, hydrogen peroxide, organic acids), competition for adhesion sites and
nutrients on the intestinal epithelium, enhancement of the intestinal epithelial barrier,
regulation of neurotransmitter synthesis and gut–brain signaling pathways, and
immunomodulation. Although the beneficial effects of probiotics on host health have
been extensively studied, many mechanisms at the molecular level are still incompletely
understood. Further research is needed to better understand these processes and to
develop effective alternatives for the prevention and treatment of infections. The
importance of probiotics in this context is growing, as inappropriate use of antibiotics
has led to increasing levels of antibiotic resistance. |
| Sekundarne ključne besede: |
probiotic;mechanism of action;Lactobacillus spp.;Bifidobacterium spp.;antimicrobial substance;competitive exclusion;epithelial barrier;immunomodulation; |
| Vrsta dela (COBISS): |
Diplomsko delo/naloga |
| Študijski program: |
0 |
| Komentar na gradivo: |
Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije |
| Strani: |
1 spletni vir (1 datoteka PDF (VI, 20 str.)) |
| ID: |
27211648 |