diplomsko delo
Nena Velkova (Author), Simona Strnad (Mentor), Lidija Fras Zemljič (Co-mentor)

Abstract

Razvoj hemokompatibilnih biomaterialov predstavlja izjemen izziv, saj so kardiovaskularni zapleti glavni vzrok smrti ljudi v razvitem svetu. Raziskave so zato v zadnjem času usmerjene v iskanje protitrombogenih substanc rastlinskega izvora. Cilj diplomskega dela je bil kemično modificirati ksilane različnih izvorov v smislu pridobitve protitrombogenih lastnosti ter jih aplicirati na vlaknih. Rezultati so pokazali, da je bil uporabljeni postopek sulfatacije primeren za obdelavo uporabljenih vzorcev ksilanov. Aktivirani delni tromboplastinski čas (APTT) se po sulfataciji značilno zviša v primerjavi z nesulfatiranimi vzorci. APTT se zviša z višjo vsebnostjo sulfatnih skupin v vzorcu. Po sulfatiranju postanejo ksilani topni v vodi in torej primerni za aplikacijo na vlaknih.

Keywords

hemokompatibilni biomateriali;ksilani;sulfatiranje;PET;antikoagulacijske lastnosti;titracijske metode;

Data

Language: Slovenian
Year of publishing:
Source: Maribor
Typology: 2.11 - Undergraduate Thesis
Organization: UM FS - Faculty of Mechanical Engineering
Publisher: [N. Velkova]
UDC: 677.027(043.2)
COBISS: 14769686 Link will open in a new window
Views: 1795
Downloads: 134
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Other data

Secondary language: English
Secondary title: Fibre treatment with modified xylan for hemocompatibility achievement
Secondary abstract: The development of hemocompatible biomaterials represents extreme challenge, as the cardiovascular complications are a main reason of deaths in developed world. For that reason, the research is focused in searching of antithrombotic substances of plant source. The main goal of study was to chemically modify xylans from different sources, to get antithrombotic properties and to apply them on fibers. The results has shown that the used procedure of sulfation was apropriate for treatment of used samples of xylans. Activated partial thromboplastin time (APTT) inceased after sulfation, compared to non sulfated samples. APTT increased with higher content of sulfated groups in the sample. After sulfation, the xylans became water soluble and as such appropriate fibre treatment.
Secondary keywords: hemocompatible biomaterials;xylan;sulphation;PET;anticoagulation properties;titration methods;
URN: URN:SI:UM:
Type (COBISS): Undergraduate thesis
Thesis comment: Univ. v Mariboru, Fak. za strojništvo, Tekstilstvo
Pages: IV, 50 f.
Keywords (UDC): applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;various industries;trades and crafts;razne industrije;obrti in rokodelstva;textile industry;tekstilna industrija;
ID: 1012765
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