Gap junctions and epileptic seizures - two sides of the same coin?

Vladislav Volman (Author), Matjaž Perc (Author), Maxim Bazhenov (Author)

Abstract

Electrical synapses (gap junctions) play a pivotal role in the synchronization of neuronal ensembles which also makes them likely agonists of pathological brain activity. Although large body of experimental data and theoretical considerations indicate that coupling neurons by electrical synapses promotes synchronous activity (and thus is potentially epileptogenic), some recent evidence questions the hypothesis of gap junctions being among purely epileptogenic factors. In particular, an expression of inter-neuronal gap junctions is often found to be higher after the experimentally induced seizures than before. Here we used a computational modeling approach to address the role of neuronal gap junctions in shaping the stability of a network to perturbations that are often associated with the onset of epileptic seizures. We show that under some circumstances, the addition of gap junctions can increase the dynamical stability of a network and thus suppress the collective electrical activity associated with seizures. This implies that the experimentally observed post-seizure additions of gap junctions could serve to prevent further escalations, suggesting furthermore that they are a consequence of an adaptive response of the neuronal network to the pathological activity. However, if the seizures are strong and persistent, our model predicts the existence of a critical tipping point after which additional gap junctions no longer suppress but strongly facilitate the escalation of epileptic seizures. Our results thus reveal a complex role of electrical coupling in relation to epileptiform events. Which dynamic scenario (seizure suppression or seizure escalation) is ultimately adopted by the network depends critically on the strength and duration of seizures, in turn emphasizing the importance of temporal and causal aspects when linking gap junctions with epilepsy.

Keywords

epilepsija;nelinearna dinamika;električne sinapse;sklopitev;sinhronizacija;epilepsy;nonlinear dynamics;electrical synapses;coupling;synchronization;

Data

Language:	English
Year of publishing:	2011
Typology:	1.01 - Original Scientific Article
Organization:	UM FNM - Faculty of Natural Sciences and Mathematics
UDC:	530.16
COBISS:	18706184
ISSN:	1932-6203
Views:	656
Downloads:	351
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	epilepsija;nelinearna dinamika;električne sinapse;sklopitev;sinhronizacija;
URN:	URN:SI:UM:
Type (COBISS):	Scientific work
Pages:	str. e20572-1-e20572-11
Volume:	ǂVol. ǂ6
Issue:	ǂiss. ǂ5
Chronology:	2011
DOI:	10.1371/journal.pone.0020572
ID:	10843423