S kapecitabinom povzročen transmuralni miokardni infarkt

Miroslav Vujasinović (Author), Marko Boc (Author), Zdenko Kikec (Author), Cirila Slemenik-Pušnik (Author)

Abstract

Fluoropirimidini so citostatiki, ki jih uvrščamo med tako imenovane antimetabolite (zaviralce celične presnove). Pomembna predstavnika te skupine sta 5-fluorouracil (5-FU) in kapecitabin (peroralni analog 5-FU), ki spadata v skupino t.i. pirimidinskih analogov. Oba predstavljata temelj vseh kemoterapevtskih shem, ki jih uporabljamo pri zdravljenju solidnih tumorjev prebavil in sta kot taka nepogrešljiva pri zdravljenju le-teh. Med redkejše neželene učinke obeh spada kardiotoksičnost, med drugim tudi miokardni infarkt. Spekter s kapecitabinom oz. 5-FU povzročene kardiotoksičnosti je širok in med drugim poleg miokardnega infarkta vključuje angino pektoris, aritmije, kongestivno odpoved srca, kardiogeni šok in nenadno srčno smrt. Zaradi množične uporabe v onkološkem zdravljenju različnih solidnih tumorjev, moramo biti pozorni tudi na možnost kardiotoksičnosti, še posebej pri bolnikih z pridruženo znano ishemično boleznijo srca. Predstavljamo primer bolnice brez predhodno znanih kardiovaskularnih bolezni, pri kateri je prišlo do razvoja transmuralnega miokardnega infarkta tekom terapije s kapecitabinom.

Keywords

kapecitabin;kemoterapija;kardiotoksičnost;srčni infarkt;miokardni infarkt;

Data

Language:	Slovenian
Year of publishing:	2015
Typology:	1.04 - Professional Article
Organization:	OI - Institute of Oncology
UDC:	616.127-005.8
COBISS:	2140283
ISSN:	1408-1741
Parent publication:	Onkologija
Views:	3093
Downloads:	652
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Capecitabine-induced transmural myocardial infarction : case report
Secondary abstract:	Fluoropyrimidine are agents that comprise the so-called antimetabolites (inhibitors of cell metabolism). An important representatitve of this group are 5-fluorouracil (5-FU) and capecitabine (an oral analog of 5-FU), which belong to a group called pyrimidine analogs. Both represent the cornerstone of chemotherapy regimens, which are used in the treatment of solid tumors of the gastrointestinal tract and are indispensable in the treatment thereof. Among the rare side-effects of both appears cardiotoxicity including myocardial infarction. The spectrum of capecitabine-induced cardiotoxicity is wide and icludes angina, arrhythmias, myocardial infarction and death. Due to its increasing use in oncologic therapy, specialists should be aware of cardiotoxicity especially when used in patients with the history of ishaemic heart disease. We present a case of a female patient without previous cardiovascular symptoms who developed transmural myocardial infarction during the treatment with capecitabine.
URN:	URN:NBN:SI
Pages:	str. 33-34, 38
Volume:	ǂLetn. ǂ19
Issue:	ǂšt. ǂ1
Chronology:	jun. 2015
ID:	10917361