Presejanje - iskanje mutacij v tumorskem supresorskem genu Tp53 z uporabo DGGEin sekveniranja

Alenka Ličar (Author), Srdjan Novaković (Author)

Abstract

Mutacije v genu Tp53 so dokazane pri več kot 50 % malignih bolezni. Pri številnih malignih bolezni je vloga mutacij v tem genu neposredno povezana z nastankom raka. Namen našega prispevka je posredovati informacijo o metodoloških pristopih, s katerimi določamo mutacije v genu Tp53 na Oddelku za molekularno diagnostiko Onkološkega inštituta Ljubljana.

Keywords

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Data

Language:	Slovenian
Year of publishing:	2008
Typology:	1.03 - Short Scientific Article
Organization:	OI - Institute of Oncology
UDC:	616-006
COBISS:	25340121
ISSN:	1408-1741
Parent publication:	Onkologija
Views:	2075
Downloads:	473
Average score:	0 (0 votes)
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Other data

Secondary language:	English
Secondary title:	Screening for Mutations in Tp53 Tumor Suppressor Gene using DGGE and Sequencing
Secondary abstract:	Mutations in the T53 gene have been detected in more than 50% of different malignancies. The development of many of these diseases is directly associated with the mutations in the Tp53 gene. The aim of this article is to provide information about new methods that have been introduced into our Department of Molecular Diagnostics at the Institute of Oncology Ljubljana for scanning mutations in the Tp53 gene.
Secondary keywords:	Genes, tumor suppressor;Genes, p53;Physiology;Mutation;Genetics;Polymerase chain reaction;Electrophoresis;Genetic counseling;Genetic screening;Neoplasms;
URN:	URN:NBN:SI
Source comment:	BSDOCID143384;
Pages:	str. 122-124
Volume:	ǂLetn. ǂ12
Issue:	ǂšt. ǂ2
Chronology:	2008
ID:	10956495