Zdravljenje bolnikov s ploščatoceličnim karcinomom glave in vratu z obsevanjem in cetuksimabom

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Language:	Slovenian
Year of publishing:	2008
Typology:	1.04 - Professional Article
Organization:	OI - Institute of Oncology
UDC:	616-006
COBISS:	701051
ISSN:	1408-1741
Parent publication:	Onkologija
Views:	1949
Downloads:	416
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Secondary language:	English
Secondary title:	Treatment of Patients with Squamous Cell Carcinoma of the Head and Neck with Concomitant Irradiation and Cetuximab
Secondary abstract:	Contemporary management of locally and regionally advanced squamous cell carcinoma of the head and neck combines simultaneous application of radiotherapy and chemotherapy. With more comprehensive understanding of radiobiological principles of radiotherapy and recent developments in biological drug modeling and technology, more room was provided for improving some other areas of treatment. One of the new promising strategies in the treatment of head and neck carcinomas is the inhibition of epidermal growth factor receptor (EGFR) signaling using anti-EGFR monoclonal antibodies (e.g. cetuximab, Erbitux). In this article, we present the first two patients treated at the Institute of Oncology Ljubljana with the combination of irradiation and cetuximab and discuss theoretical background for the new treatment regime and other possible therapeutic indications for cetuximab in head and neck oncology.
URN:	URN:NBN:SI
Source comment:	BSDOCID143366;
Pages:	str. 84-88
Volume:	ǂLetn. ǂ12
Issue:	ǂšt. ǂ2
Chronology:	dec. 2008
ID:	10957600