towards fingerprinting breath
I. R. White (Author), Kerry A. Willis (Author), Chris Whyte (Author), Rebecca L. Cordell (Author), Robert S. Blake (Author), Andrew J. Wardlaw (Author), Satish S. C. Rao (Author), Jonathan Grigg (Author), Andrew Michael Ellis (Author), Paul S. Monks (Author)

Abstract

The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.

Keywords

volatile organic compounds;breath;mass spectrometry;cystic fibrosis;proton transfer reaction;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UNG - University of Nova Gorica
UDC: 54
COBISS: 5423867 Link will open in a new window
ISSN: 1752-7163
Views: 2576
Downloads: 0
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Other data

URN: URN:SI:UNG
Type (COBISS): Not categorized
Pages: str. 1-11
Volume: ǂVol. ǂ7
Issue: ǂno. ǂ1
Chronology: 2013
DOI: 10.1088/1752-7155/7/1/017112
ID: 11192834
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