towards fingerprinting breath
I. R. White (Avtor), Kerry A. Willis (Avtor), Chris Whyte (Avtor), Rebecca L. Cordell (Avtor), Robert S. Blake (Avtor), Andrew J. Wardlaw (Avtor), Satish S. C. Rao (Avtor), Jonathan Grigg (Avtor), Andrew Michael Ellis (Avtor), Paul S. Monks (Avtor)

Povzetek

The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.

Ključne besede

volatile organic compounds;breath;mass spectrometry;cystic fibrosis;proton transfer reaction;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 54
COBISS: 5423867 Povezava se bo odprla v novem oknu
ISSN: 1752-7163
Št. ogledov: 2576
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 1-11
Letnik: ǂVol. ǂ7
Zvezek: ǂno. ǂ1
Čas izdaje: 2013
DOI: 10.1088/1752-7155/7/1/017112
ID: 11192834
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