diplomsko delo
Goran Kragolnik (Author), Mitja Kolar (Mentor)

Abstract

Konoplja je najbolj razširjena ter uporabljena droga na svetu in je človeštvu znana že več tisoč let. Kanabinoidi, ki so njene najbolj znane sestavine, igrajo neposredno vlogo pri interakciji z endokanabinoidnim sistemom pri ljudeh. V relativno kratkem času so se po svetu razširile tudi njihove sintetične različice, ki jih je težje identificirati z običajnimi analiznimi metodami. Eden boljših sistemov za določanje kanabinoidov je HPLC-QTOF. V diplomskem delu smo z HPLC-QTOF optimizirali metodo za analizo naravnih in sintetičnih kanabinoidov. Metodo smo delno validirali in dokazali, da jo je možno uporabiti tudi za kvantitativno analizo v različnih matricah. Prikazali smo fragmentacijske poti kanabinoidov in predlagali nekaj mehanizmov. Izvedli smo tudi analize realnih vzorcev in medsebojno primerjavo le-teh.

Keywords

analizna kemija;konoplja;naravni kanabinoidi;sintetični kanabinoidi;analizne metode;tekočinska kromatografija visoke ločljivosti;masni analizator na osnovi časa preleta ionov;HPLC-QTOF;validacija metode;fragmentacijski mehanizmi;diplomske naloge;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [G. Kragolnik]
UDC: 543.544.5.068.7:547.9(043.2)
COBISS: 1538328259 Link will open in a new window
Views: 921
Downloads: 258
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Other data

Secondary language: English
Secondary abstract: Cannabis is the most widespread and abused drug in the World and has been known to humanity for thousands of years. Its most known constituents, cannabinoids, play a direct role in interacting with the human endocannabinoid system. Relatively recently however, their synthetic counterparts have spread across the globe and are more difficult to detect with the usual analytical methods. One of the better instruments for determination of cannabinoids is the HPLC-QTOF. In the thesis we used the HPLC-QTOF and optimized a method for analysis of natural and synthetic cannabinoids. We partially validated the method and demonstrated that it can also be used for quantitative analysis in different matrixes. We have shown fragmentation pathways of cannabinoids and proposed some mechanisms. We also performed an analysis of real samples and their comparison.
Secondary keywords: cannabis;natural cannabinoids;synthetic cannabinoids;HPLC-QTOF;method validation;fragmentation mechanisms;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000374
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo
Pages: 53 str.
ID: 11217766