diplomsko delo
Nika Žnideršič (Author), Martin Gazvoda (Mentor)

Abstract

Cilj diplomske naloge je bila sinteza novih fluoroforov s 4-feniletinil-fenilaminskim skeletom, ki bi bili na podlagi svojih optičnih in vezavnih lastnosti primerni za detekcijo proteina tau in vitro kot tudi in vivo. Sinteza 4-(4-((4-(etil(2-fluoroetil)amino)fenil)etinil)fenil)-6-metil-2-okso-2H-piran-3-karbonitril je vključevala reakcijo Claisenove kondenzacije, pripajanje po Sonagashiri in fluoriranje. Uspešno je bil sintetiziran diketon 1-(4-((4-(etil(2-hidroksietil)amino)fenil)etinil)fenil)butan-1,3-dion, ki lahko služi kot izhodna spojina za pripravo želene končne spojine.

Keywords

organska sinteza;reakcija pripajanja;fluoriranje;molekulske sonde;fluorescenčna mikroskopija;tau proteini;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [N. Žnideršič]
UDC: 547.1.057(043.2)
COBISS: 1538425283 Link will open in a new window
Views: 792
Downloads: 258
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Other data

Secondary language: English
Secondary title: Synthesis of fluorofores with 4-phenylethynyl-phenylamine skeleton
Secondary abstract: The goal of this thesis was to synthesize new fluorophores with 4-phenylethynyl-phenylamine scaffold that would be suitable for detection of tau protein in vitro as well as in vivo, based on their optical and binding properties. Synthesis of 4-(4-((4-(ethyl(2-fluoroethyl)amino)fenyl)ethynyl)fenyl)-6-methyl-2-oxo-2H-pyran-3-carbonitrile included Claisen condensation, Sonagashira coupling and fluorination reaction. Diketone 1-(4-((4(ethyl(2-hydroxyethyl)amino)¬phenyl)ethynyl)¬phenyl)¬butane-1,3-dione was successfully synthesized and can serve as a starting compound for the synthesis of the desired compound.
Secondary keywords: molecular probe;organic synthesis;coupling reaction;fluorination reaction;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000373
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages: 28 str.
ID: 11221110