Clinical significance of histologic subtyping of malignant pleural mesothelioma

Luka Brčić (Author), Izidor Kern (Author)

Abstract

Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.

Keywords

maligni mezoteliom;epiteloidni maligni mezoteliom;bifazni maligni mezoteliom;sarkomatoidni maligni mezoteliom;malignant mesothelioma;epithelioid malignant mesothelioma;biphasic malignant mesothelioma;sarcomatoid malignant mesothelioma;

Data

Language:	English
Year of publishing:	2020
Typology:	1.02 - Review Article
Publisher:	AME Publishing Company
UDC:	616-006
COBISS:	17124867
ISSN:	2226-4477
Views:	1406
Downloads:	758
Average score:	0 (0 votes)
Metadata:

Other data

Secondary keywords:	Mesothelioma;Anatomy and histology;Analysis;Mezoteliom;Anatomija in histologija;Analiza;
Embargo end date (OpenAIRE):	0000-00-00
Source comment:	Nasl. z nasl. zaslona; Opis vira z dne 27. 5. 2020;
Pages:	str. 924-933
Volume:	ǂVol. ǂ9
Issue:	ǂiss. ǂ3
Chronology:	Jun. 2020
DOI:	10.21037/tlcr.2020.03.38
ID:	11858336