Clinical significance of histologic subtyping of malignant pleural mesothelioma

Povzetek

Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.

Ključne besede

maligni mezoteliom;epiteloidni maligni mezoteliom;bifazni maligni mezoteliom;sarkomatoidni maligni mezoteliom;malignant mesothelioma;epithelioid malignant mesothelioma;biphasic malignant mesothelioma;sarcomatoid malignant mesothelioma;

Podatki

Jezik:	Angleški jezik
Leto izida:	2020
Tipologija:	1.02 - Pregledni znanstveni članek
Založnik:	AME Publishing Company
UDK:	616-006
COBISS:	17124867
ISSN:	2226-4477
Št. ogledov:	1406
Št. prenosov:	758
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarne ključne besede:	Mesothelioma;Anatomy and histology;Analysis;Mezoteliom;Anatomija in histologija;Analiza;
Konec prepovedi (OpenAIRE):	0000-00-00
Komentar vira:	Nasl. z nasl. zaslona; Opis vira z dne 27. 5. 2020;
Strani:	str. 924-933
Letnik:	ǂVol. ǂ9
Zvezek:	ǂiss. ǂ3
Čas izdaje:	Jun. 2020
DOI:	10.21037/tlcr.2020.03.38
ID:	11858336