magistrsko delo
Tina Pečarič Strnad (Author), Bogdan Štefane (Mentor), Jurij Lah (Thesis defence commission member), Uroš Grošelj (Thesis defence commission member)

Abstract

V magistrski nalogi smo izvajali rutenij katalizirano neposredno C–H ariliranje 3-heteroarilizokinolinov, kateremu je sledilo paladij katalizirano neposredno C–H ariliranje. Uspešno smo optimizirali reakcijske pogoje obeh stopenj tako, da smo dosegli optimalno stopnjo pretvorbe. Z uporabo optimiziranih pogojev smo sintetizirali več različnih monoariliranih in nekaj diariliranih produktov. Nadalje smo optimizirane reakcijske pogoje uporabili pri izvedbi sekvenčne »one-pot« reakcije za sintezo končnih diariliranih produktov, saj nas je zanimalo ali je sekvenčna »one-pot« metoda enako učinkovita, kot če reakcijo izvedemo stopenjsko s čiščenjem vmesnega intermediata. S primerjavo izkoristkov končnih produktov smo ugotovili, da sta oba načina sinteze diariliranih produktov podobno učinkovita.

Keywords

organske reakcije;C-H aktivacija;ariliranje;izokinolini;3-heteroarilizokinolin;'one-pot';kataliza s kovinami prehoda;rutenij;paladij;magistrska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [T. Pečarič Strnad]
UDC: 547.831:66.095.257(043.2)
COBISS: 20941827 Link will open in a new window
Views: 926
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Other data

Secondary language: English
Secondary title: Ruthenium/palladium diarylation of 3-heteroarylisoquinolines
Secondary abstract: The master thesis describes ruthenium catalyzed direct C–H arylation of 3-heteroarylisoquinolines, followed by palladium catalyzed direct C–H arylation. We successfully optimized the reaction conditions of both steps to achieve the optimum conversion. Several different monoarylated and some diarylated products were synthesized using the optimized conditions. We further used the optimized conditions to perform a sequential one-pot reaction for the synthesis of the final diarylated products. We were interested in whether the sequential one-pot method was as effective as if the reactions was performed sequentially with purification of the intermediate. By comparing the yields of the products, we concluded that both modes of synthesis of diarylated products are similarly effective.
Secondary keywords: C-H activation;3-heteroarylisoquinoline;arylation;transition-metal catalysis;
Type (COBISS): Master's thesis/paper
Study programme: 1000375
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, smer Kemija
Pages: 73 str.
ID: 11868136