Pulmonary pathology and COVID-19

lessons from autopsy

Fiorella Calabrese (Author), Federica Pezzuto (Author), Francesco Fortarezza (Author), Paul Hofman (Author), Izidor Kern (Author), Angel Panizo (Author), Jan von der Thüsen (Author), Sergei Timofeev (Author), Gregor Gorkiewicz (Author), Francesca Lunardi (Author)

Abstract

Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19) has quickly spread to a pandemic infectious disease. The causative agent has been recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines are available nor any specific treatment. To limit the number of infections, strict directives have been issued by governments that have been translated into equally rigorous guidelines notably for post-mortem examinations by international and national scientific societies. The recommendations for biosafety control required during specimen collection and handling have strongly limited the practice of autopsies of the COVID-19 patients to a few adequate laboratories. A full pathological examination has always been considered an important tool to better understand the pathophysiology of diseases, especially when the knowledge of an emerging disorder is limited and the impact on the healthcare system is significant. The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies. Ancillary tools such as electron microscopy and molecular biology used on autoptic tissue samples from autopsy are also significantly contributing to confirm and/or identify new aspects useful for a deeper knowledge of the pathogenetic mechanisms. This article will review and summarize the pathological findings described in COVID-19 until now, chiefly focusing on the respiratory tract, highlighting the importance of autopsy towards a better knowledge of this disease.

Keywords

covid-19;SARS-CoV-2;COVID-19;

Data

Language:	English
Year of publishing:	2020
Typology:	1.02 - Review Article
Publisher:	Springer Nature
UDC:	616.2
COBISS:	23930627
ISSN:	1432-2307
Views:	12364
Downloads:	676
Average score:	0 (0 votes)
Metadata:

Other data

Secondary keywords:	Coronavirus;Pandemics;Lung;Pathology;Autopsy;Koronavirus;Pandemije;Pljuča;Patologija;Obdukcija;
Source comment:	Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 29. 7. 2020;
Pages:	str. 359-372
Volume:	ǂVol. ǂ477
Issue:	ǂiss. ǂ3
Chronology:	Sept. 2020
DOI:	10.1007/s00428-020-02886-6
ID:	11928335