diplomsko delo
Abstract
Diplomsko delo opisuje sintezo nove, v literaturi še neopisane soli piridina s triazolilidenskim fragmentom vezanim na piridinski dušikov atom. Sintetizirana sol predstavlja potencialni bidentatni dikarbenski NHC ligand, uporaben za tvorbo NHC kompleksov s kovinami prehoda. Sintezo smo izvedli v šestih korakih, kjer smo najprej po literaturno znanih postopkih ločeno pripravili izhodni alkin, 1-etinil-4-fenilpiridin-1-ijev trifluorometansulfonat, in benzil azid. V nadaljevanju smo izvedli klik reakcijo med želenim alkinom in azidom, pri čemer smo dobili ustrezni triazol, 1-(1-benzil-1H-1,2,3-triazol-4-il)-4-fenilpiridin-1-ijev trifluorometansulfonat. Kot katalizator smo uporabili Cu(PPh3)3Br. V zadnjem koraku smo triazol metilirali na mestu N3 in tako prišli do končnega produkta, 1-(1-benzil-3-metil-1H-1,2,3-triazol-3-ijev-4-il)-4-fenilpiridin-1-ijevega trifluorometansulfonata. Končnega produkta nam žal ni uspelo očistiti, saj je razpadel na SiO2 koloni.
Keywords
1,2,3-triazol;triazolijeve soli;soli piridina;triazoliliden;ligand;klik reakcija;diplomska dela;
Data
Language: |
Slovenian |
Year of publishing: |
2020 |
Typology: |
2.11 - Undergraduate Thesis |
Organization: |
UL FKKT - Faculty of Chemistry and Chemical Technology |
Publisher: |
[L. Jedlovčnik] |
UDC: |
547.79:547.82(043.2) |
COBISS: |
30426883
|
Views: |
444 |
Downloads: |
111 |
Average score: |
0 (0 votes) |
Metadata: |
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Other data
Secondary language: |
English |
Secondary title: |
Synthesis of novel pyridinium salt containing triazolylidene fragment |
Secondary abstract: |
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes. The synthesis was performed in six steps, where the starting alkyne, 1-ethynyl-4-phenylpyridin-1-trifluoromethanesulfonate, and benzyl azide, were independently prepared according to the literature reports. Following, a Cu(PPh3)3Br catalyzed click reaction between the desired alkyne and azide was performed to give the corresponding triazole, 1- (1-benzyl-1H-1,2,3-triazol-4-yl) -4-phenylpyridin-1-yl trifluoromethanesulfonate. In the last step, the triazole was methylated at the N3 position to give the final product, 1- (1-benzyl-3-methyl-1H-1,2,3-triazol-3-yl-4-yl) -4-phenylpyridin- 1-trifluoromethanesulfonate. Unfortunately, the final product was not purified, due to its decomposition on a SiO2 column. |
Secondary keywords: |
1,2,3-triazole;click reaction;triazolylidene;ligand; |
Type (COBISS): |
Bachelor thesis/paper |
Study programme: |
1000373 |
Embargo end date (OpenAIRE): |
1970-01-01 |
Thesis comment: |
Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija |
Pages: |
32 str. |
ID: |
12031350 |