Sinteza in optične lastnosti nekaterih N,N-dimetil-4-(feniletinil)anilinov

diplomsko delo

Petra Kremžar (Author), Janez Košmrlj (Mentor)

Abstract

Tauopatija je nevrodegenerativno bolezensko stanje, ki nastane kot posledica genske predispozicije, travmatičnih poškodb možganov in patološkega stresa. Med taupatije uvrščamo Alzheimerjevo, Parkinsonovo, Creutzfeld-Jacobovo bolezen in druge. Prepoznavanje začetka bolezni je ključno in v ta namen se iščejo molekulske sonde z zadovoljivimi vezalnimi in optičnimi lastnostmi za fluoroscenčno mikroskopijo in pozitronsko emisijsko tomografijo v medicini in biologiji. V tem delu predstavljamo teoretična izhodišča sinteze derivatov N,N-dimetil-4-(feniletinil)anilina z različnimi elektron akceptorskimi skupinami z namenom boljših optičnih in vezavnih lastnosti za uporabo v fluorescenčni mikroskopiji.

Keywords

taupatija;tau proteini;molekulske sonde;fluorofor;Sonogashira spajanje;diplomska dela;

Data

Language:	Slovenian
Year of publishing:	2020
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[P. Kremžar]
UDC:	547.551(043.2)
COBISS:	30403587
Views:	560
Downloads:	149
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Synthesis and optical properties of some N,N-dimethyl-4-(phenylethinyl)anilines
Secondary abstract:	Tauopathy is a neurodegenerative disease which occurs as a consequence of genetic predisposition, traumatic injuries to the brain and pathological stress. Tauopathy diseases include Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease and others. Investigation of the early onset of these diseases is crucial. With this aim molecular probes with sufficient binding and optical properties are being investigated for the use in fluorescence microscopy and positron emission tomography imaging. In this work we present theoretical background for the synthesis of N,N-dimethyl-4-(phenylethinyl)aniline derivatives with different electron acceptor goups, with a hope for better optical and binding properties for the use in fluorescence microscopy.
Secondary keywords:	molecular probe;fluorophore;Sonogashira coupling;tau proteins;taupathy;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000373
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages:	34 str.
ID:	12031353